Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNA sequencing profiling of placental tissues from placenta accreta and control pregnancies

ABSTRACT: RNA sequencing profiling of placental tissues from placenta accreta and control pregnancies

PROVIDER: PRJNA626612 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR11575068_1.fastq.gz	Fastqsanger.gz
	SRR11575068_2.fastq.gz	Fastqsanger.gz
	SRR11575069_1.fastq.gz	Fastqsanger.gz
	SRR11575069_2.fastq.gz	Fastqsanger.gz
	SRR11575070_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 20

Similar Datasets

RNA sequencing profiling of placental tissues from placenta accreta and control pregnancies

Project description:Placenta accreta is a major cause of maternal morbidity and mortality in modern obstetrics. The study aims to identify the differently expressed lncRNA and mRNA in placenta accreta patients compared with controls and to determine biological pathways, which provides a novel insight ingto thepathogenesis of placneta accreta.

2021-12-29 | GSE148952 | GEO

Proteomics profiling of placental tissues from placenta accreta and control pregnancies

Project description:Placenta accreta is a major cause of maternal morbidity and mortality in modern obstetrics. The study aims to identify the differently expressed proteins in placenta accreta patients compared with controls and to determine biological pathways, which provides a novel insight into the pathogenesis of placneta accreta.

2020-04-19 | PXD018665 |

Dysregulated lncRNA and mRNA expression in placenta accreta spectrum disorders

Project description:To find potential biomarkers and molecular mechanism for placenta accreta spectrum disorders , we identified the differently expressed patterns of lncRNAs and mRNAs in invasive placneta and adherent normal placenta tissues. The results provided a novel insight into the pathogenesis of placenta accreta spectrum disorders .

2020-02-14 | GSE126552 | GEO

Discovery of diagnostic biomarker and molecular mechanisms of placenta accreta spectrum

Project description:Transcriptome analysis of FFPE placenta of placenta accreta spectrum, over increta. Pre-diagnosis is essential to safely deal with placenta accrete spectrum, but definitive diagnostic markers have not yet been established. We conducted a transcriptome analysis of FFPE placenta to establish early diagnostic markers for placenta accreta.

2023-11-01 | GSE189267 | GEO

Identification of altered miRNAs and their targets in Placenta Accreta

Project description:We aim to elucidate regulatory miRNA and target networks contributing to Placenta accreta spectrum development using smallRNA-Seq.

2022-11-01 | GSE216742 | GEO

Placental Accreta Spectrum: Upregulated Cytotrophoblast DOCK4 Contributes to Over Invasion

Project description:In humans, a subset of placental cytotrophoblasts (CTBs) invades the uterus and its vasculature, anchoring the pregnancy and ensuring adequate blood flow to the fetus. Appropriate depth is critical. Shallow invasion increases the risk of pregnancy complications, e.g., severe preeclampsia. Overly deep invasion, the hallmark of placenta accreta spectrum (PAS), increases the risk of pre-term delivery, hemorrhage and death. Previously a rare condition, the incidence of PAS has increased to 1:731 pregnancies, likely due to the rise in uterine surgeries (e.g., Cesarean sections). CTBs track along the scars deep into the myometrium and beyond. Here we compared the global gene expression patterns of CTBs from PAS cases to gestational age-matched control cells that invaded to the normal depth from preterm birth (PTB) deliveries. The mRNA encoding the guanine nucleotide exchange factor, DOCK4, mutations of which promote cancer cell invasion and angiogenesis, was the most highly differentially expressed molecule in PAS samples. Over-expression of DOCK4 increased CTB invasiveness, consistent with the PAS phenotype. Also, this analysis identified other genes with significantly altered expression in this disorder, potential biomarkers. These data suggest that CTBs from PAS cases up regulate a cancer-like pro-invasion mechanism, suggesting molecular as well as phenotypic similarities in the two pathologies.

2019-09-30 | GSE136048 | GEO

Single-Cell Analysis of Placenta Accreta Spectrum: Novel Contribution of Endothelial Cells to the Pathogenesis of Disease

Project description:This study utilizes advances in single-cell RNA-sequencing to generate transcriptomes from placenta accreta and control specimens.

2024-02-05 | GSE212505 | GEO

Chorionic membranes show molecular changes in placenta previa and placenta accreta spectrum

Project description:Chorionic membranes show molecular changes in placenta previa and placenta accreta spectrum

| PRJNA655528 | ENA

Chorionic membranes show molecular changes in placenta previa and placenta accreta spectrum

Project description:Chorionic membranes show molecular changes in placenta previa and placenta accreta spectrum

| PRJNA655529 | ENA

Term placenta tissue-level transcriptome

Project description:We provide the tissue-level human placental transcriptomes from two term uncomplicated pregnancies. Tissue was collected at term C-section (no labor), from villous part of the placenta.

2017-01-31 | GSE87708 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data