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Repeat tick exposure elicits distinct immune responses in guinea pigs and mice

ABSTRACT: Repeat tick exposure elicits distinct immune responses in guinea pigs and mice

PROVIDER: PRJNA626632 | ENA |

REPOSITORIES: ENA

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Repeat tick exposure elicits distinct immune responses in guinea pigs and mice [guinea pig]

Project description:Repeat tick exposure elicits distinct immune responses in guinea pigs and mice [guinea pig]

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Repeat tick exposure elicits distinct immune responses in guinea pigs and mice [guinea pig]

Project description:RNA-seq gene expression analysis of guinea pig and mouse skin after tick bites

2023-04-20 | GSE148967 | GEO

Repeat tick exposure elicits distinct immune responses in guinea pigs and mice [mouse]

Project description:RNA-seq gene expression analysis of guinea pig and mouse skin after tick bites

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Repeat tick exposure elicits distinct immune responses in guinea pigs and mice [mouse]

Project description:Repeat tick exposure elicits distinct immune responses in guinea pigs and mice [mouse]

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Immunzition of Salp14-C mRNA and lipid nanoparticles elicited multiple immune response to tick challenge in guinea pig skin

Project description:In this study, we immunized guinea pigs with mRNA of Salp14 C terminus and lipid nanoparticles (LNP), the animals produced high titers of IgG, and developed moderate erythema during tick challenge, the transcriptomes of skin at tick bite sites enriched multiple immune response pathways, which might be involved in erythema development.

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mRNA vaccination induces tick resistance and prevents transmission of the Lyme Disease agent

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Plasma Biomarkers for VX exposure in guinea pigs

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Repeat tick exposure elicits distinct immune responses in guinea pigs and mice

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-04-20 | GSE148969 | GEO

Repeat tick exposure elicits distinct immune responses in guinea pigs and mice.

Project description:Ticks deposit salivary proteins into the skin during a bite to mediate acquisition of a blood meal. Acquired resistance to tick bites has been demonstrated to prevent Borrelia burgdorferi sensu lato (s.l.) transmission. However, the mechanism of resistance, as well as the protective antigens, have remained elusive. To address these unknowns, we utilized a guinea pig model of tick resistance and a mouse model of permissiveness. Guinea pigs developed immunity after multiple Ixodes scapularis tick infestations, characterized by rapid tick detachment and impaired feeding. In comparison, mice tolerated at least 6 infestations with no significant impact on feeding. We analyzed the bite sites by RNA-sequencing and histology, identifying several inflammatory pathways in tick immune animals, such as FcεRI signaling and complement activation, and activation of coagulation pathways that could impair local blood flow. Together, these results identify important pathways altered during tick rejection and potential tick proteins that could serve as vaccine candidates.

| S-EPMC7530331 | biostudies-literature

miRNA levels in caput and cauda sperm in adult male guinea pigs following synthetic glucocorticoid exposure

Project description:It has been demonstrated that males exposed to adversity prior to conception sire offspring exhibiting abnormal behaviour and neuroendocrine function. Epigenetic factors such as microRNA (miRNA) within sperm may be responsible for driving these effects. Synthetic glucocorticoids (sGC) are a class of drug that are commonly prescribed and may have implications for intergenerational transmission. Therefore, we hypothesized that caput and cauda sperm miRNA profiles will be altered following sGC exposure in guinea pigs. We used miRNA microarray to evaluate the miRNA levels of caput and cauda sperm isolated from guinea pigs exposed to control and water treated with sGC. We identified a subset of miRNAs with low levels in cauda sperm of guinea pigs exposed to sGC.

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