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Pharmacologic or genetic inhibition of EphB3 receptor kinase impacts CNS pathology during progressive EAE

ABSTRACT: Pharmacologic or genetic inhibition of EphB3 receptor kinase impacts CNS pathology during progressive EAE

PROVIDER: PRJNA627395 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11588000_1.fastq.gz	Fastqsanger.gz
	SRR11588000_2.fastq.gz	Fastqsanger.gz
	SRR11588001_1.fastq.gz	Fastqsanger.gz
	SRR11588001_2.fastq.gz	Fastqsanger.gz
	SRR11587970_1.fastq.gz	Fastqsanger.gz

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Pharmacologic or genetic inhibition of EphB3 receptor kinase impacts CNS pathology during progressive EAE

Project description:We evaluated the role of EphB3 on the regulation of astrocyte and microglial responses and its potential as a therapeutic target during progressive EAE. We induced EAE in NOD mice that will develop a progressive form of the disease. Starting at the beginning of the progressive phase, A38 was administered and alternatively EphB3 was KD in astrocytes. Both treatments ameliorated the EAE. The transcriptional analysis of astrocytes and microglia revealed the decreased expression of genes associated to inflammation and neurodegeneration in both conditions.

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Eph Receptor B3/EphrinB3 signaling impact CNS pathology during EAE

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Project description:We aimed to investigate the role of EphB3 and EfnB3 on the regulation of astrocyte and microglial responses in the context of CNS inflammation, we KD Efnb3 in microglia or EphB3 in astrocytes both resulting in a comparable amelioration of EAE. The transcriptional analysis of the two cell types revealed the decreased expression of genes associated to inflammation and neurodegeneration in both KD conditions.

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Pharmacologic inhibition of EphB3 receptor kinase ameliorates EAE

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