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MiRNA expression in Th17 cells after AhR activation

ABSTRACT: miRNA expression in Th17 cells after AhR activation

PROVIDER: PRJNA627682 | ENA |

REPOSITORIES: ENA

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miRNA expression in Th17 cells after AhR activation

Project description:Th17 cells play a major role in the pathogenesis of Rheumatoid Arthritis, and it is well known the involvement of the Aryl Hydrocarbon Receptor (AhR) during the differentiation and activation of these cells. Due to its function as a transcription factor, we tested wether AhR would mediate part of its function in Th17 cells through the transcription of microRNAs (miRNAs). Therefore, we first perform a microarray experiment to identify the miRNAs induced after AhR activation in Th17 cells. Under a supervised hierarchical clustering, we identify 224 miRNAs differentially expressed (fold-change ³ 2.0 and FDR < 5%). Among them, 22 miRNAs were up regulated exclusively in Th17 cells in the presence of FICZ.

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Project description:The objective of this study was to analyze AHR activation through aromatic amino acid metabolism. To this end, glioblastoma cells were exposed to aromatic amino acid derived metabolites and their ability to activate AHR was analysed. In addition, AHR activation was evaluated in glioblastoma cells expressing IL4I1, an aromatic amino acid degrading enzyme, with or without shRNA mediated knockdown of AHR.

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miRNA-seq study between Th0 and Th17 cells

Project description:To explore the differences in miRNA profiles, naive CD4+CD62L+ helper T cells were sorted by magnetic cell sorting from spleens of female C57BL/6 mice and were induced to differentiate into Th1 or Th17 cells, then total RNA was extracted and miRNA-seq were conducted. The results showed that many microTNAs presented a different expression pattern between Th1 and Th17 cells, which prompted us to further study their roles in Th117 differenciation. miRNA profiles of Th0 and Th17 cells were generated by deep sequencing, in triplicate, using Illumina HiSeq 2500

2016-07-30 | E-GEOD-80834 | biostudies-arrayexpress

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