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RNA-seq analysis of Eubacterium limosum KIST612 across different carbon/energy/electron sources and growth phases.

ABSTRACT: RNA-seq analysis of Eubacterium limosum KIST612 across different carbon/energy/electron sources and growth phases.

PROVIDER: PRJNA627859 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11604235_1.fastq.gz	Fastqsanger.gz
	SRR11604235_2.fastq.gz	Fastqsanger.gz
	SRR11604236_1.fastq.gz	Fastqsanger.gz
	SRR11604236_2.fastq.gz	Fastqsanger.gz
	SRR11604237_1.fastq.gz	Fastqsanger.gz

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RNA-seq analysis of Eubacterium limosum KIST612 across different carbon/energy/electron sources and growth phases.

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Project description:Eubacterium limosum ATCC 8486 makes acetate and butyrate from various substrates and is found in the human intestine. The proteome of gamma-butyrobetaine -grown Eubacterium limosum was obtained in order to identify enzymes required for growth on gamma-butyrobetaine, in particular to identify components that are unique to growth on gamma-butyrobetaine in comparison to other substrates for acetogenesis, such as lactic acid, L-carnitine, or proline betaine. Gamma-butyrobetaine is converted to trimethylamine (TMA) by certain members of the gut microbiome. Subsequent liver metabolism of TMA is now tied to progression of cardiovascular disease. Demethylation of gamma-butyrobetaine is observed during growth of Eubacterium limosum on this substrate, and does not produce TMA. Gamma-butyrobetaine demethylation by organisms like Eubacterium limosum could lessen TMA production in the gut, thereby lessening the propensity towards atherosclerosis caused by metabolism of TMA in the body. This proteome led to discovery of gamma-butyrobetaine:tetrahydrofolate methyltransferase system. The key gamma-butyrobetaine demethylating enzyme is a member of the widespread TMA methyltransferase protein superfamily.

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