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Human gut metagenome

ABSTRACT: Gut microbiota features and risk of acquiring antibiotic resistant organisms in nursing home patients

PROVIDER: PRJNA627982 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11607901_1.fastq.gz	Fastqsanger.gz
	SRR11607901_2.fastq.gz	Fastqsanger.gz
	SRR11607902_1.fastq.gz	Fastqsanger.gz
	SRR11607902_2.fastq.gz	Fastqsanger.gz
	SRR11607903_1.fastq.gz	Fastqsanger.gz

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Project description:This SuperSeries is composed of the SubSeries listed below. We analyzed the effects of antibiotics using a popular model of gut microbiota depletion in mice by a cocktail of antibiotics. We combined intestinal transcriptome together with metagenomic analysis of the gut microbiota to develop a new bioinformatics approach that probes the links between microbial components and host functions. We found that most antibiotic-induced alterations can be explained by three factors: depletion of the microbiota; direct effects of antibiotics on host tissues; and the effects of remaining antibiotic-resistant microbes. While microbe depletion led to down-regulation of immunity, the two other factors primarily inhibited mitochondrial gene expression and amounts of active mitochondria, and induced cell death. By reconstructing and analyzing a transkingdom network, we discovered that these toxic effects were mediated by virulence/quorum sensing in antibiotic-resistant bacteria.

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