Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Loss of cyclin A2 in murine colonic epithelial cells disrupts colon homeostasis by triggering DNA damage and dysplasia and high cyclin A2 expression is a good-prognosis factor in patients with colorectal cancer

ABSTRACT: Loss of cyclin A2 in murine colonic epithelial cells disrupts colon homeostasis by triggering DNA damage and dysplasia and high cyclin A2 expression is a good-prognosis factor in patients with colorectal cancer

PROVIDER: PRJNA629794 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR11680528_1.fastq.gz	Fastqsanger.gz
	SRR11680528_2.fastq.gz	Fastqsanger.gz
	SRR11680529_1.fastq.gz	Fastqsanger.gz
	SRR11680529_2.fastq.gz	Fastqsanger.gz
	SRR11680530_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 16

Similar Datasets

Loss of cyclin A2 in murine colonic epithelial cells disrupts colon homeostasis by triggering DNA damage and dysplasia and high cyclin A2 expression is a good-prognosis factor in patients with colorectal cancer

Project description:To clarify the function of cyclin A2 in colon homeostasis and colorectal cancer (CRC) we generated mice deficient for cyclin A2 in colonic epithelial cells (CEC). Colons of those mice displayed architectural changes in the mucosa, and signs of inflammation as well as an increased proliferation of CEC associated with the appearance of low- and high-grade dysplasia. The main initial events triggering those alterations in cyclin A2 deficient CEC appear to be abnormal mitoses and DNA damage. Cyclin A2 deletion in CEC promoted the development of dysplasia and adenocarcinomas in the murine colitis-associated cancer model.

2020-12-01 | GSE149716 | GEO

Cyclin A2 endometrial deficiency and early pregnancy loss

Project description:Cyclin A2 endometrial deficiency and early pregnancy loss

| PRJNA1136835 | ENA

Cyclin A2 endometrial deficiency and early pregnancy loss

Project description:Proper action of the female sex steroids, 17β-estradiol (E2) and progesterone (P4) on endometrium is essential for fertility. Beyond its role in regulating the cell cycle, cyclin A2 (CCNA2) also mediates E2 and P4 signaling in vitro, but a potential role in modulating steroid action for proper endometrial tissue development and function is unknown. To fill this gap in our knowledge, we examined human endometrial tissue from fertile and infertile women for CCNA2 expression and correlated this with pregnancy outcome. Functional assessment of CCNA2 was validated in vivo using a conditional Ccna2 uterine deficient mouse model while in vitro function was assessed using human cell culture models. We found that CCNA2 expression was significantly reduced in endometrial tissue, specifically the stromal cells, from women undergoing in vitro fertilization who failed to achieve pregnancy. Conditional deletion of Ccna2 from mouse uterine tissue recapitulated the inability to achieve successful pregnancy which appears to be due to alterations in the process of decidualization, which was confirmed using in vitro models. From these studies, we conclude that CCNA2 expression during the proliferative/regenerative stage of the menstrual cycle acts as a safeguard allowing for proper steroid responsiveness, decidualization and pregnancy. When CCNA2 expression levels are insufficient there is impaired endometrial responsiveness, aberrant decidualization and loss of pregnancy.

2024-10-14 | GSE272413 | GEO

Pseudomonas sp. A2 strain:A2

Project description:Pseudomonas sp. A2 strain:A2 Genome sequencing

| PRJNA531364 | ENA

Gluconacetobacter sp. A2 strain:A2

Project description:Gluconacetobacter sp. A2 strain:A2 Clone ends

| PRJNA254777 | ENA

Gluconacetobacter sp. A2 strain:A2

Project description:Gluconacetobacter sp. A2 strain:A2 Clone ends

| PRJNA256230 | ENA

Halohasta sp. A2 strain:A2

Project description:Halohasta sp. A2 strain:A2 Genome sequencing