Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptomic analysis of kidney cortex following podocyte-loss of Klf4

ABSTRACT: Transcriptomic analysis of kidney cortex following podocyte-loss of Klf4

PROVIDER: PRJNA630232 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR11684900.fastq.gz	Fastqsanger.gz
	SRR11684901.fastq.gz	Fastqsanger.gz
	SRR11684902.fastq.gz	Fastqsanger.gz
	SRR11684903.fastq.gz	Fastqsanger.gz
	SRR11684904.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 18

Similar Datasets

Transcriptomic analysis of kidney cortex following podocyte-loss of Klf4

Project description:The goal of this study was to identify transcriptomic changes of mouse kidney cortex in mice with podocyte-specific deletion of Kruppel-like factor 4, a zinc-finger transcription factor.

2021-09-22 | GSE149818 | GEO

Transcriptomic analysis of glomeruli and kidney cortex following podocyte-loss of Klf4

Project description:Transcriptomic analysis of glomeruli and kidney cortex following podocyte-loss of Klf4

| PRJNA630225 | ENA

Transcriptomic analysis of glomeruli following podocyte-loss of Klf4

Project description:Transcriptomic analysis of glomeruli following podocyte-loss of Klf4

| PRJNA630231 | ENA

Gene expression profile at single cell level of podocyte-specific I-PpoI expressing mice kidney cortex

Project description:To investigate the alterations in cell populations in the kidney after podocyte DNA DSBs, we performed single-cell RNA sequencing (scRNA-seq) on the renal cortex of 12-week-old podocyte-specific I-PpoI expressing mice that had not yet developed glomerulosclerosis or fibrosis.

2022-12-26 | GSE220478 | GEO

Transcriptomic analysis of glomeruli following podocyte-loss of Klf4

Project description:The goal of this study was to identify transcriptomic changes of mouse glomeruli in mice with podocyte-specific deletion of Kruppel-like factor 4, a zinc-finger transcription factor.

2021-09-22 | GSE149817 | GEO

Transcriptomic analysis of glomeruli and kidney cortex following podocyte-loss of Klf4

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-09-22 | GSE149819 | GEO

Transcriptomic analysis of kidney cortex following the loss of functional Sco2

Project description:The goal of this study was to identify transcriptomic changes caused by loss of functional Sco2 in kidney cortex of db/db mice (Type II Diabetes Mellitus mouse model).

2022-01-26 | GSE171722 | GEO

Podocyte-specific induction of Krüppel-like factor 15 restores differentiation markers and attenuates kidney injury in proteinuric kidney disease

Project description:Podocyte injury is the hallmark of proteinuric kidney diseases, such as Focal Segmental Glomerulosclerosis and Minimal Change Disease. Therapeutic strategies in the management of proteinuric diseases are limited. Although agents such as glucocorticoids, cyclosporine, and rituximab have direct effects on the podocyte by stabilizing its actin cytoskeleton, these drugs are riddled with systemic toxicity and off-target effects that hinder their chronic use. We previously demonstrated that the loss of the kidney-enriched zinc finger transcription factor, Krüppel-like factor 15 (KLF15), increases susceptibility to proteinuric kidney disease as well as attenuates the salutary effects of retinoic acid and glucocorticoids in the podocyte. Here, we show that podocyte-specific induction of KLF15, using the tetracycline-inducible system, attenuated podocyte injury, glomerulosclerosis, tubulointerstitial fibrosis and inflammation, while improving renal function and overall survival in HIV-1 transgenic mice. Enrichment analysis of mRNA sequencing of isolated glomerular extracts from this model shows that podocyte-specific induction of KLF15 activates pathways involved in stabilization of actin cytoskeleton, focal adhesion, and podocyte differentiation. Transcription factor enrichment analysis, with further experimental validation, suggests that KLF15 activity is in part mediated by Wilms Tumor 1 (WT1), a transcription factor known to be critical for podocyte differentiation. Further, we confirmed the benefits of podocyte-specific induction of KLF15 in the adriamycin-induced proteinuric murine model. Collectively, these observations suggest that induction of KLF15 might be a potential therapeutic target in the treatment of proteinuric kidney disease.

2018-08-02 | GSE117987 | GEO

Transcriptomic analysis of kidney cortex following the loss of functional Sco2

Project description:Transcriptomic analysis of kidney cortex following the loss of functional Sco2

| PRJNA720659 | ENA

Single cell transcriptomics reveal disrupted kidney filter cell-cell interactions after early and selective podocyte injury

Project description:We recently demonstrated that podocyte ablation via doxycycline-inducible deletion of an essential endogenous molecule, CTCF (iCTCFpod-/-), is sufficient to drive progressive CKD. However, the earliest events connecting podocyte injury to disrupted intercellular communication within the kidney filter remain unclear. Here we performed single-cell RNA sequencing of kidney tissue from iCTCFpod-/- mice after one week of doxycycline induction to generate a map of the earliest transcriptional effects of podocyte injury on cell-cell interactions at single cell resolution

2021-05-09 | GSE174102 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data