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The long noncoding RNA and mRNA expression profiles of human temporomandibular joint synovial fluid derived mesenchymal stem cell altered by IL-1β

ABSTRACT: The long noncoding RNA and mRNA expression profiles of human temporomandibular joint synovial fluid derived mesenchymal stem cell altered by IL-1β

PROVIDER: PRJNA631004 | ENA |

REPOSITORIES: ENA

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The long noncoding RNA and mRNA expression profiles of human temporomandibular joint synovial fluid derived mesenchymal stem cell altered by IL-1β

Project description:Synovial fluid derived mesenchymal stem cells (SFMSC) play an important regulatory role in the physiological balance of the temporomandibular joint. IL-1β, as an important pathogenic factor of temporomandibular joint disorders, can affect the biological behaviors of SFMSC, such as inflammatory activation and chondrogenic differentiation. The functional roles of lncRNA and mRNA expression profiles in SFMSC altered by IL-1β are undefined. The aim of this study is to identify the lncRNA and mRNA expression profiles of SFMSC altered by IL-1β.

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Project description:We performed gene expression profiling analysis using data obtained from RNA-seq of 2 different cells from post-traumatic temporomandibular joint osteoarthritis model to investigate the signaling pathways critical for cellular functions during temporomandibular joint osteoarthritis pathology.

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