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Voltage-gated Sodium Channel SCN5A Promotes Tumor Progression and Enhances Chemosensitivity to 5-Fluorouracil in Colorectal Cancer

ABSTRACT: Voltage-gated Sodium Channel SCN5A Promotes Tumor Progression and Enhances Chemosensitivity to 5-Fluorouracil in Colorectal Cancer

PROVIDER: PRJNA631241 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11735727_1.fastq.gz	Fastqsanger.gz
	SRR11735727_2.fastq.gz	Fastqsanger.gz
	SRR11735728_1.fastq.gz	Fastqsanger.gz
	SRR11735728_2.fastq.gz	Fastqsanger.gz
	SRR11735729_1.fastq.gz	Fastqsanger.gz

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Voltage-gated Sodium Channel SCN5A Promotes Tumor Progression and Enhances Chemosensitivity to 5-Fluorouracil in Colorectal Cancer

Project description:SCN5A was reported to promote proliferation and invasiveness potential in colorectal cancer, yet the mechanism was not clarified, and little was known about its association with chemosensitivity to 5-fluorouracil. In the current study, elevated SCN5A expression were associated with poor prognosis and metastasis in colorectal cancers, whereas stage II-III patients with up-regulated SCN5A expression were more likely to benefit from 5-fluorouracil-based adjuvant chemotherapy. SCN5A could promote proliferation and invasiveness potential through regulating cell cycle and epithelial-mesenchymal transition in colorectal cancer cells. Furthermore, SCN5A regulated Ras signaling by stabilizing KRas-calmodulin complex through Ca2+ influx. Apart from that, under 5-fluorouracil treatment, SCN5A promoted calmodulin-dependent apoptosis in colorectal cancers.

2020-05-09 | GSE150134 | GEO

Regulation of fin regeneration by a voltage-gated sodium channel

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Roles of voltage-gated potassium channels in the maintenance of pancreatic cancer stem cells

Project description:The targeting of membrane proteins that are activated in cancer stem cells (CSCs) represents one of the key strategies in novel cancer therapy. The present study investigated ion channel expression profiles and functions in pancreatic CSCs (PCSCs). Cells strongly expressing aldehyde dehydrogenase 1 family member A1 (ALDH1A1) were separated from PK59 cells, a human pancreatic cancer cell line, using fluorescence-activated cell sorting (FACS), and PCSCs were identified based on tumorsphere formation. A microarray analysis was performed to investigate gene expression profiles in PCSCs. ALDH1A1 messenger RNA levels were higher in PCSCs. PCSCs were resistant to 5-fluorouracil (5-FU) and capable of re-differentiation. The microarray analysis revealed that gene expression related to ion channels, including voltage-gated potassium channels (Kv), was up-regulated. 4-Aminopyridine (4-AP), a potent Kv inhibitor, exhibited greater cytotoxicity in PCSCs. In a xenograft model in nude mice, tumor volumes were significantly smaller in mice injected with PK59 cells treated with 4-AP than in those injected with non-treated cells. The present results implicate Kv in the persistence of PCSCs, and the Kv inhibitor, 4-AP, has potential as a therapeutic agent for pancreatic carcinoma.

2021-04-16 | GSE172185 | GEO

SCN5A

Project description:Monodelphis domestica SCN5A, Monodelphis domestica sodium voltage-gated channel alpha subunit 5 (SCN5A), mRNA. [Source:RefSeq mRNA;Acc:NM_001246327], is expressed in 1 baseline experiment(s);

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Impact of the Voltage-Gated Calcium Channel Antagonist Nimodipinedipine on the Development of Oligodendrocyte Precursor Cells

Project description:We investigated the effects of nimodipine, a L-type voltage-gated calcium channel antagonist, on the expression profile of myelin genes in the oligodendrocyte precursor cell (OPC) line Oli-Neu. We performed gene expression profiling analysis using data obtained from RNA-seq of four biological replicates for treatment and four replicates for control condition.

2023-03-30 | GSE221939 | GEO

Scn5a

Project description:Rattus norvegicus Scn5a, sodium voltage-gated channel alpha subunit 5 [Source:RGD Symbol;Acc:3637], is differentially expressed in 15 experiment(s);

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Scn5a

Project description:Rattus norvegicus Scn5a, sodium voltage-gated channel alpha subunit 5 [Source:RGD Symbol;Acc:3637], is expressed in 5 baseline experiment(s);

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Scn5a

Project description:Mus musculus Scn5a, sodium channel, voltage-gated, type V, alpha [Source:MGI Symbol;Acc:MGI:98251], is differentially expressed in 64 experiment(s);

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SCN5A

Project description:Homo sapiens SCN5A, sodium voltage-gated channel alpha subunit 5 [Source:HGNC Symbol;Acc:HGNC:10593], is expressed in 33 baseline experiment(s);

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SCN5A

Project description:Sus scrofa SCN5A, sodium voltage-gated channel alpha subunit 5 [Source:VGNC Symbol;Acc:VGNC:92637], is differentially expressed in 1 experiment(s);

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