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ScRNAseq of CD45+ cells within PDAC tumors treateted with CD40/ICB

ABSTRACT: scRNAseq of CD45+ cells within PDAC tumors treateted with CD40/ICB

PROVIDER: PRJNA631402 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11744032.fastq.gz	Fastqsanger.gz
	SRR11744033.fastq.gz	Fastqsanger.gz
	SRR11744034.fastq.gz	Fastqsanger.gz
	SRR11744035.fastq.gz	Fastqsanger.gz
	SRR11744036.fastq.gz	Fastqsanger.gz

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scRNAseq of CD45+ cells within PDAC tumors treateted with CD40/ICB

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Project description:To induce leukemia in NOD/SCID/γc−/− (NSG) mice, we injected 10^5 human B-ALL cells, into the tail vein of non-irradiated mice. Two different PDX mice models were studied (PDX-1; #1 and PDX-2; #2). The InVivoMAb anti-human CD40 antibody (BE0189, clone G28.5, BioXCell) was i.v. administrated (CD40) at the dose of 1 mg/kg, the same was done with the recommended isotype (Ig) (BE0083, MOPC-21, BioXCell). We administrated antibodies, at days 15 and 25. At day 35, when mice developed leukemia, B-ALL cells were purified from the BM of PDX-mice, with magnetic beads-conjugated to human CD45 antibodies. Three mice per condition were tested (replicat 1 to 3; mice m1 to m3).

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