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Changes of gene expression patterns of human cancer cell lines responding to Interferon-gamma

ABSTRACT: Changes of gene expression patterns of human cancer cell lines responding to Interferon-gamma

PROVIDER: PRJNA631734 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11772172.fastq.gz	Fastqsanger.gz
	SRR11772173.fastq.gz	Fastqsanger.gz
	SRR11772174.fastq.gz	Fastqsanger.gz
	SRR11772175.fastq.gz	Fastqsanger.gz
	SRR11772176.fastq.gz	Fastqsanger.gz

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Changes of gene expression patterns of human cancer cell lines responding to Interferon-gamma

Project description:We report the differences of gene expression pattern of 4 different human cancer cell lines responding to Interferon-gamma. 4 different human cancer cell lines were treated with 20ng/ml of Interferon-gamma for 72 hours and gathered for RNA seq. We found that in response to Interferon-gamma, cancer cell lines expressed increased amounts of RNA related to immune responses.

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Changes of gene expression patterns of Mouse TC-1 cell lines responding to Interferon-gamma [TC-1 cell line]

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Project description:The cytokine interferon-gamma (IFN-gamma) is used as a drug to treat Chronic Granulomatous Disease (CGD), a group of genetic disorders characterized by defects in components of the neutrophil-resident NADPH oxidase/Nox2 enzyme system. Administration of IFN-gamma to these patients results in decreased incidents of severe infection, but has no effect on the characteristic defect of CGD, the inability to convert oxygen to microbicidal reactive oxygen species. To determine the mechanism by which IFN-gamma enhances the host protective properties of neutrophils, we administered INF-gamma to 10 healthy adult volunteers and carried out transcription profiling by array for neutrophils isolated from their peripheral blood. IFN-gamma was administered to each subject at 4 doses (10, 25, 50 and 100 micrograms/meter squared) with washout periods between each dose. Gene expression levels in neutrophils were measure just before (time 0) and at various times (4, 8, 12, 24, 36, 48, 72 and 96 hours) after administration of IFN-gamma. In the list of samples, individual patients are indicated by 01-10, the dose by D10, D25, D50 and D100, referring to 10, 25, 50 and 100 micrograms / meter squared respectively and the times by visit (V) numbers where VI, V2, V3, V4, V5, V6, V7, V8 and V9 refer to the 0 4, 8, 12, 24, 36, 48, 72 and 96 hour time points respectively.

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