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Transcriptomic changes resulting from STK32B overexpression identifies pathways potentially relevant to essential tremor

ABSTRACT: Transcriptomic changes resulting from STK32B overexpression identifies pathways potentially relevant to essential tremor

PROVIDER: PRJNA631971 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11777741_1.fastq.gz	Fastqsanger.gz
	SRR11777741_2.fastq.gz	Fastqsanger.gz
	SRR11777742_1.fastq.gz	Fastqsanger.gz
	SRR11777742_2.fastq.gz	Fastqsanger.gz
	SRR11777743_1.fastq.gz	Fastqsanger.gz

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Similar Datasets

Transcriptomic changes resulting from STK32B overexpression identifies pathways potentially relevant to essential tremor

Project description:We report RNA sequencing of overexpressed STK32B in DAOY cells compared to matched controls, with 200M reads per sample. We identified approximately 4000 differentially expressed genes and potential pathways relevant to essential tremor.

2020-05-13 | GSE150393 | GEO

Transcriptomic Changes Resulting From <i>STK32B</i> Overexpression Identify Pathways Potentially Relevant to Essential Tremor.

Project description:Objective: Essential tremor (ET) is a common movement disorder that has a high heritability. A number of genetic studies have associated different genes and loci with ET, but few have investigated the biology of any of these genes. STK32B was significantly associated with ET in a large genome-wide association study (GWAS) and was found to be overexpressed in ET cerebellar tissue. The objective of this study is to determine the effects of overexpressed STK32B in cerebellar DAOY cells. Methods: Here, we overexpressed STK32B RNA in human cerebellar DAOY cells and used an RNA-Seq approach to identify differentially expressed genes (DEGs) by comparing the transcriptome profile of these cells to one of the control DAOY cells. Results: Pathway and gene ontology enrichment identified axon guidance, olfactory signaling, and calcium-voltage channels as significant. Additionally, we show that overexpressing STK32B affects transcript levels of previously implicated ET genes such as FUS. Conclusion: Our results investigate the effects of overexpressed STK32B and suggest that it may be involved in relevant ET pathways and genes.

| S-EPMC7413243 | biostudies-literature

Gene Expression Analysis of Essential Tremor via RNA-sequencing

Project description:RNA-seq evaluation of post-mortem human cerebelllum from 33 patients with diagnosed Essential tremor, compared to 22 age-matched control patients. Two samples were under-sequenced and therefore removed from the final analysis. The raw data has been included in this submission.

2019-07-26 | GSE134878 | GEO

Next Generation Sequencing Facilitated Cerebellum DNA Methylation Analysis of Essential Tremor Patients

Project description:We report the RRBS-based cerebellum DNA methylation profiling of essential tremor (ET) patients and controls. By obtaining over thirty billion bases of sequence from bisulfited-converted DNA, we generated genome-wide methylation profile of human cerebellum tissue. We identified differential DNA methylation patterns in 735 genes at various gene parts, across 12 ET patients. Many of those differentially methylated CpGs in ET patients are located in upstream regulatory regions of genes. We further found that many differentially methylated genes in ET pateints are associated with neurodegenerative disease. This study provided a framework towards understanding epigenetic alteration in cerebellum of essnetial tremor patients.

2020-02-04 | GSE134426 | GEO

Dissecting the Genetic Underpinnings of Essential Tremor

Project description:Dissecting the Genetic Underpinnings of Essential Tremor

| PRJNA402111 | ENA

Identification of Susceptibility Genes for Essential Tremor

Project description:Identification of Susceptibility Genes for Essential Tremor

| PRJNA290967 | ENA

Columbia-Yale-Bilkent Study: Genetics Study of Essential Tremor

Project description:Columbia-Yale-Bilkent Study: Genetics Study of Essential Tremor

| PRJNA422644 | ENA

Gene Expression Analysis of Essential Tremor via RNA-sequencing

Project description:Gene Expression Analysis of Essential Tremor via RNA-sequencing

| PRJNA556679 | ENA

Columbia-Yale-Bilkent Study: Genetics Study of Essential Tremor

Project description:Columbia-Yale-Bilkent Study: Genetics Study of Essential Tremor

| PRJNA422643 | ENA

Family Study of Essential Tremor (FASET)

Project description:<p>The Familial Study of Essential Tremor (FASET) was designed to identify susceptibility genes for Essential Tremor. ET is among the most common neurological diseases with a prevalence (age > 40 years) estimated to be 4.0% and prevalence in advanced age (' 90 years) exceeding 20%. ET, often referred to as "familial tremor", is generally regarded as a highly genetic disorder with families with affecteds over multiple generations, and twin studies showing high concordance among monozygotic twins. Probands (affected with ET) and relatives were enrolled in a family study of ET at Columbia University, New York between 2011 - 2014. The study was approved by the Institutional Review Board at Columbia University and written informed consent was obtained from all enrollees. The criteria for enrollment were: 1) the proband had early-onset ET with age at onset < 50 years, 2) the proband had a diagnoses of definite or probable ET, 3) in addition to the proband there were at least two affected relatives in the family, 4) additional affected and unaffected family members were willing to participate in the study, and 5) the families contained more than two affected individuals in different generations. Blood samples were also collected for genetic research. For the genetic analyses, we excluded enrollees whom we or others had diagnosed with Parkinson's disease (PD) or dystonia. The final sample includes 52 families (52 probands [affected with ET]) and 155 relatives). The number of affected individuals enrolled per family ranged from 3 - 7 (mean = 4.1). Genetic samples from FASET were analyzed with whole genome SNP genotyping (for linkage analyses) and whole exome sequencing. It is hoped that this resource will better help researchers to understand the genetic causes of ET and underlying disease pathogenesis.</p>

| phs000966 | dbGaP

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