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DNA methylation profiles of F1 mice sperm of the control group and arsenic group

ABSTRACT: DNA methylation profiles of F1 mice sperm of the control group and arsenic group

PROVIDER: PRJNA632597 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11785721_1.fastq.gz	Fastqsanger.gz
	SRR11785721_2.fastq.gz	Fastqsanger.gz
	SRR11785722_1.fastq.gz	Fastqsanger.gz
	SRR11785722_2.fastq.gz	Fastqsanger.gz
	SRR11785723_1.fastq.gz	Fastqsanger.gz

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DNA methylation profiles of F1 mice sperm of the control group and arsenic group

Project description:Pregnant C3H mice were given tap water (control group) and tap water containing 85 ppm sodium arsenite from gestational day 8 to 18 (arsenic group), respectively. The DNA methylomes of sperm of F1 mice were investigated by RRBS method. The results showed that gestational arsenic exposure increased hypomethylated cytosines in the F1 sperm genome. The present study has indicated environmental impacts on sperm DNA methylome establishment.

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DNA methylation profiles of F1 mice sperm of the control group and arsenic group II

Project description:Pregnant C3H mice were given tap water (control group) and tap water containing 85 ppm sodium arsenite from gestational day 8 to 18 (arsenic group), respectively. The DNA methylomes of sperm of F1 mice were investigated by RRBS method. The results showed that gestational arsenic exposure increased hypomethylated cytosines in active retrotransposon subfamilies. The present study has indicated environmental impacts on sperm DNA methylome establishment.

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DNA methylation profiles of F1 mice sperm of the control group and arsenic group II

Project description:DNA methylation profiles of F1 mice sperm of the control group and arsenic group II

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DNA methylation profiles of mice embryos (E7.5) of the control group and arsenic group

Project description:The control or gestationally arsenic exposed F1 males (C3H strain) and C57BL/6 strain (B6) females were crossed and F2 male embryos were obtained on embryonic day 7.5 (E7.5). The DNA methylomes of the embryos were investigated by RRBS method.

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DNA methylation profiles of mice embryos (E7.5) of the control group and arsenic group_2nd experiment

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DNA methylation profiles of mice embryos (E7.5) of the control group and arsenic group

Project description:DNA methylation profiles of mice embryos (E7.5) of the control group and arsenic group

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Project description:Birth cohort studies and experimental investigations in animals link gestational diabetes mellitus (GDM) with impaired cognitive performance in the first filial generation (F1). We found that intrauterine hyperglycemia exposure resulted in behavior abnormality and cognitional functional disorder of both F1- and F2-GDM male mice. Methylome of sperm of F1 adult male mice from control pregnant mice (F1-C) and GDM pregnant mice (F1-GDM) revealed differentially methylated genes enriched in neurodevelopmental process.

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Project description:Adult male mice (F0) were exposed to 250 ppb inorganic arsenic (iAs) in drinking water before mating with unexposed female mice to generate male F1 offspring (iAsF1-M). Unexposed male mice were bred simultaneously to generate male controls (conF1-M). Both iAsF1-M and conF1-M mice drank normal water without iAs. Adult iAsF1-M and conF1-M mice were harvested to collect liver samples to do RNA-seq.

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2017-06-20 | GSE96850 | GEO

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