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Inducible smooth muscle specific deletion of Yap1/Wwtr1 in mouse

ABSTRACT: Inducible smooth muscle specific deletion of Yap1/Wwtr1 in mouse

PROVIDER: PRJNA632892 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11791238_1.fastq.gz	Fastqsanger.gz
	SRR11791238_2.fastq.gz	Fastqsanger.gz
	SRR11791239_1.fastq.gz	Fastqsanger.gz
	SRR11791239_2.fastq.gz	Fastqsanger.gz
	SRR11791240_1.fastq.gz	Fastqsanger.gz

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Inducible smooth muscle specific deletion of Yap1/Wwtr1 in mouse [Thoracic aorta RNA-seq]

Project description:Inducible smooth muscle specific deletion of Yap1/Wwtr1 in mouse [Thoracic aorta RNA-seq]

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Inducible smooth muscle specific deletion of Yap1/Wwtr1 in mouse

Project description:YAP and TAZ are transcriptional co-activators and downstream effectors of the Hippo pathway, which play crucial roles in organ size control and cancer pathogenesis. Genetic deletion of YAP/TAZ has revealed their critical importance for embryonic development of the heart, vasculature and gastrointestinal mesenchyme. The aim of this study was to determine the functional role of YAP/TAZ in adult smooth muscle cell in vivo.

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Inducible smooth muscle specific deletion of Yap1/Wwtr1 in mouse [Thoracic aorta RNA-seq]

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YAP1 and WWTR1 are required for murine pregnancy initiation

Project description:Endometrial stromal cell decidualization is required for pregnancy success. Although this process is integral to fertility, many of the intricate molecular mechanisms contributing to decidualization remain undefined. One pathway that has been implicated in endometrial stromal cell decidualization in humans in vitro, is the Hippo signaling pathway. Two previously conducted studies showed that the effectors of the Hippo signaling pathway, YAP1 and WWTR1, were required for decidualization of primary stromal cells in culture. To investigate the in vivo role of YAP1 and WWTR1 in decidualization and pregnancy initiation, we generated a Progesterone Cre mediated partial double knockout (pdKO) of Yap1 and Wwtr1. Female pdKOs exhibited subfertility, a compromised decidualization response, partial interruption in embryo transport, blunted endometrial receptivity, delayed implantation and subsequent embryonic development, and a unique transcriptional profile. Bulk mRNA sequencing revealed aberrant maternal remodeling evidenced by significant alterations in extracellular matrix proteins at 7.5 days post coitus in pdKO dams, and enrichment for terms associated with fertility compromising diseases like pre-eclampsia and endometriosis. Our results indicate a required role for YAP1 and WWTR1 for successful mammalian uterine function and pregnancy success.

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RNA-seq data set of EGFR mutant human non-small cell lung cancer cell lines PC9, HCC827, HCC4006 after NF2 knockout, YAP1 or WWTR1 overexpression or osimertinib treatment

Project description:Experiment was designed to study the effect of Hippo pathway on osimertinib resistance in non-small cell lung cancer cell lines. The specific comparisons investigated were: PC-9: NTC vs NF2 KO, EV vs YAP1 OE, EV vs WWTR1 OE, EV DMSO treated vs EV osimertinib treated HCC827: NTC vs NF2 KO, EV vs YAP1 OE, EV vs WWTR1 OE,EV DMSO treated vs EV osimertinib treated HCC4006: NTC vs NF2 KO, EV vs YAP1 OE, EV vs WWTR1 OE, EV DMSO treated vs EV osimertinib treated

2024-07-01 | E-MTAB-13831 | biostudies-arrayexpress

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Project description:Yap1 and Wwtr1 were knocked down via siRNA in primary murine alveolar cells derived from normal or fibrotic mice (PBS treated as a control for bleomycin instilled animals, harvested at 14 days). Isolated cells from three independent isolations were plated on tissue culture plates and allowed to adhere for 2 days followed by incubation with siRNA via forward transfection. Samples were harvested 48 hours later for microarray analysis.

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YAP1 and WWTR1 are required for murine pregnancy initiation

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