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Transcriptional analysis of induced trophoblast stem cells and their derived placenta subtypes.

ABSTRACT: Transcriptional analysis of induced trophoblast stem cells and their derived placenta subtypes.

PROVIDER: PRJNA632917 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11791800.fastq.gz	Fastqsanger.gz
	SRR11791801.fastq.gz	Fastqsanger.gz
	SRR11791802.fastq.gz	Fastqsanger.gz
	SRR11791780.fastq.gz	Fastqsanger.gz
	SRR11791781.fastq.gz	Fastqsanger.gz

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Transcriptional analysis of induced trophoblast stem cells and their derived placenta subtypes.

Project description:We report the transcriptional analysis of induced trophoblast stem cells (iTSCs) and their derived plancenta subtypes including syncytiotrophoblasts (STs) and extravillous trophoblasts (EVTs).

2020-05-15 | GSE150616 | GEO

Establishment and comparison of human term placenta-derived trophoblast cells

Project description:We established an immortalized term placenta-derived trophoblast cell line and demonstrated functional and transcriptomic differences against chorion trophoblasts and BeWo cells.

2024-10-23 | GSE250585 | GEO

Transcriptomic profile of human placenta derived trophoblast organoid cultures with its tissue of origin, human placental villi.

Project description:The aim of this microarray experiment was to compare the overall transcriptomic profile of human placenta derived trophoblast organoid cultures with its tissue of origin, human placental villi. As the placental villi contains both trophoblast and stromal populations, we have included placenta derived stromal cultures in this comparison.

2018-11-28 | E-MTAB-6683 | biostudies-arrayexpress

Establishment and comparison of human term placenta-derived trophoblast cells

Project description:Establishment and comparison of human term placenta-derived trophoblast cells

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Trophoblast syncytialization maintains the placenta-heart axis

Project description:The developmental connection between the placenta and certain embryonic organs, such as the heart, is associated with normal pregnancy and complications, but how the placenta governs embryonic cardiogenesis is poorly understood. Trophoblasts fuse into a multinucleated syncytiotrophoblast (SynT) layer, primarily consisting of a placental materno-fetal interface. We identify that endogenous progesterone immunomodulatory binding factor 1 (PIBF1) is essential for trophoblast differentiation and fusion into SynT in human trophoblasts and mouse placentas. Moreover, SynT-derived PIBF1 enables the communication between SynT and adjacent vascular cells to develop the vascular network in the primary placenta and further impacts the early development of the embryonic cardiovascular system in an endocrine manner. Thus, SynT-derived factors and SynT itself in the placenta may play crucial roles in the proper organogenesis of other organs in the embryo.

2024-01-06 | GSE229265 | GEO

Chromosomal instability in human trophoblast stem cells and placenta

Project description:The human placenta, a unique tumor-like organ, is typically thought to exhibit rare aneuploidy associated with adverse pregnancy outcomes. Discrepancies in reported aneuploidy prevalence in placenta likely stem from limitations in modeling and the resolution of detection methods. Here, we used isogenic trophoblast stem cells (TSCs) derived from both naïve and primed human pluripotent stem cells (hPSCs) to reveal the spontaneous occurrence of aneuploidy, suggesting chromosomal instability (CIN) as an inherent feature of the trophoblast lineage. We identified potential pathways contributing to the occurrence and tolerance of CIN. These findings were further validated using single-cell multiome data from healthy human placentas, where we observed a high prevalence of heterogeneous aneuploidy across trophoblast cells. Despite extensive chromosomal abnormalities, TSCs maintained their proliferative and differentiation capacities, suggesting that CIN is a typical aspect of placental development. Our study challenges the traditional view of aneuploidy in the placenta and provides new insights into the role of CIN in normal placental function.

2025-03-31 | GSE280832 | GEO

Transcriptomic features of trophoblast lineage cells derived from BMP4-treated human induced pluripotent stem cells

Project description:We explored the trophoblast differentiation model using human induced pluripotent stem cells (hiPSCs) to gain new insights into the early development of human placenta. In our previous study, we have optimized culture conditions for hiPSC-derived trophoblasts. To identify the characteristics of trophoblast lineage cells derived from BMP4-treated hiPSCs, we collected cells using a pan-trophoblast marker, KRT7, with flow cytometry and performed comprehensive gene expression analysis.

2019-01-31 | GSE124832 | GEO

Trophoblast epithelial-mesenchymal transition (EMT) in abnormally invasive placenta (AIP)

Project description:Comparison of genes associated with the EMT between cytotrophoblast cells (CTB) and extravillous trophoblast cells (EVT) from normal third trimester placenta and abnormally invasive placenta (AIP)

2018-01-01 | GSE104350 | GEO

Trophoblast syncytialization maintains the placenta-heart axis

Project description:Trophoblast syncytialization maintains the placenta-heart axis

| PRJNA953770 | ENA

Stem cell-derived trophoblast organoids model human placental development and susceptibility to emerging pathogens

Project description:Trophoblast organoids derived from placental villi provide a 3D model system of human placental development, but access to first-trimester tissues is limited. Here we report that trophoblast stem cells isolated from naïve human pluripotent stem cells (hPSCs) can efficiently self-organize into 3D stem cell-derived trophoblast organoids (SC-TOs) with a villous architecture similar to primary trophoblast organoids. Single cell transcriptome analysis reveals the presence of distinct cytotrophoblast and syncytiotrophoblast clusters and a small cluster of extravillous trophoblasts, which closely correspond to trophoblast identities in the post-implantation embryo. These organoid cultures display clonal X chromosome inactivation patterns previously described in the human placenta. We further demonstrate that SC-TOs exhibit selective vulnerability to emerging pathogens (SARS-CoV-2 and Zika virus), which correlates with expression levels of their respective entry factors. The generation of trophoblast organoids from naïve hPSCs provides an accessible 3D model system of the developing placenta and its susceptibility to emerging pathogens.

2022-04-29 | GSE172241 | GEO

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