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RNA-Sequencing results of EPB41-depletion PC9 cells and control cells

ABSTRACT: RNA-Sequencing results of EPB41-depletion PC9 cells and control cells

PROVIDER: PRJNA634011 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11816662_1.fastq.gz	Fastqsanger.gz
	SRR11816662_2.fastq.gz	Fastqsanger.gz
	SRR11816663_1.fastq.gz	Fastqsanger.gz
	SRR11816663_2.fastq.gz	Fastqsanger.gz
	SRR11816664_1.fastq.gz	Fastqsanger.gz

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RNA-Sequencing results of EPB41-depletion PC9 cells and control cells

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Project description:The non-small cell lung carcinoma (NSCLC) PC9 cell line is an established preclinical model for tyrosine kinase inhibitors. To better understand gene expression changes in cells that survived the inhibitor treatment, we treated the EGFR-mutant PC9 cells with erlotinib, isolated RNA, and performed RNA-seq analysis. We were able to identify genes that are differentially expressed in erlotinib-treated cells compared to untreated. The results of this study will be integrated with single cell RNA-seq to address the utility of bulk RNA versus single cell RNA strategies in identifying biomarkers of drug resistance.

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Project description:To investigate the possible resistant mechanism to osimertinib, PC9 cells and their derived osimertinib-resistant PC9OR cells were sequenced using illumina HiSeq. We then performed gene expression profiling analysis using data obtained from RNA-seq of PC9 cells and their derived PC9OR cells.

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Project description:The non-small cell lung carcinoma (NSCLC) PC9 cell line is an established preclinical model for tyrosine kinase inhibitors. Recent evidence suggests that the H3K4 demethylase KDM5A protein is required for emerging drug-resistant cell populations. To better understand the dependence of cell survival on H3K4me3 level, we treated the EGFR-mutant PC9 cells with erlotinib and performed ChIP-seq analysis using H3K4me3 antibodies. We were able to identify genomic regions that exhibit decreased H3K4me3 in drug-treated cells. The results of this study will help to address clinical usefulness of KDM5A-targeted strategies in overcoming drug resistance, particularly in NSCLC.

2020-12-19 | GSE148461 | GEO

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