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A ubiquitin ligase mediates target-directed microRNA decay independently of tailing and trimming [miRNA-seq]

ABSTRACT: A ubiquitin ligase mediates target-directed microRNA decay independently of tailing and trimming [miRNA-seq]

PROVIDER: PRJNA635672 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11869025.fastq.gz	Fastqsanger.gz
	SRR11869026.fastq.gz	Fastqsanger.gz
	SRR11869027.fastq.gz	Fastqsanger.gz
	SRR11869028.fastq.gz	Fastqsanger.gz
	SRR11869029.fastq.gz	Fastqsanger.gz

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A ubiquitin ligase mediates target-directed microRNA decay independently of tailing and trimming

Project description:A ubiquitin ligase mediates target-directed microRNA decay independently of tailing and trimming

| PRJNA636177 | ENA

A ubiquitin ligase mediates target-directed microRNA decay independently of tailing and trimming [TDMD]

Project description:MicroRNAs (miRNAs) act in concert with Argonaute (AGO) proteins to broadly repress mRNA targets. After AGO loading, miRNAs generally exhibit slow turnover. An important exception occurs when miRNAs encounter targets with extensive complementarity, which can trigger a process termed target-directed microRNA degradation (TDMD). Prevailing models of TDMD invoke miRNA tailing and trimming as an essential step in the decay mechanism. Here, a genome-wide screen revealed a novel cullin-RING ubiquitin ligase, which we named the DECAY complex, that mediates TDMD. The DECAY complex interacts with AGO proteins, mediates TDMD induced by multiple transcripts, and does not require tailing and trimming to elicit miRNA turnover. Based upon these findings, we propose a model in which the DECAY complex mediates TDMD by promoting proteasomal decay of miRNA-containing complexes.

2020-11-13 | GSE151516 | GEO

A ubiquitin ligase mediates target-directed microRNA decay independently of tailing and trimming [miRNA-seq]

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A ubiquitin ligase mediates target-directed microRNA decay independently of tailing and trimming [small RNA-seq]

2020-11-13 | GSE158025 | GEO

A ubiquitin ligase mediates target-directed microRNA decay independently of tailing and trimming [TDMD]

Project description:A ubiquitin ligase mediates target-directed microRNA decay independently of tailing and trimming [TDMD]

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A ubiquitin ligase mediates target-directed microRNA decay independently of tailing and trimming [small RNA-seq]

Project description:A ubiquitin ligase mediates target-directed microRNA decay independently of tailing and trimming [small RNA-seq]

| PRJNA663788 | ENA

A ubiquitin ligase mediates target-directed microRNA decay independently of tailing and trimming.

Project description:MicroRNAs (miRNAs) act in concert with Argonaute (AGO) proteins to repress target messenger RNAs. After AGO loading, miRNAs generally exhibit slow turnover. An important exception occurs when miRNAs encounter highly complementary targets, which can trigger a process called target-directed miRNA degradation (TDMD). During TDMD, miRNAs undergo tailing and trimming, suggesting that this is an important step in the decay mechanism. We identified a cullin-RING ubiquitin ligase (CRL), containing the substrate adaptor ZSWIM8, that mediates TDMD. The ZSWIM8 CRL interacts with AGO proteins, promotes TDMD in a tailing and trimming-independent manner, and regulates miRNA expression in multiple cell types. These findings suggest a model in which the ZSWIM8 ubiquitin ligase mediates TDMD by directing proteasomal decay of miRNA-containing complexes engaged with highly complementary targets.

| S-EPMC8177725 | biostudies-literature

A ubiquitin ligase mediates target-directed microRNA decay independently of tailing and trimming

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-11-12 | GSE151517 | GEO

Ubiquitin ligase COP1 suppresses microglia-mediated inflammation

Project description:Ubiquitin ligase COP1 suppresses microglia-mediated inflammation

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The ubiquitin ligase HUWE1 regulates hematopoietic stem cell maintenance and lymphoid commitment [microarray]

Project description:We identified the ubiquitin ligase Huwe1 as a crucial regulator of hematopoietic stem cell (HSC) functions. We generated Huwe1 conditional knock-out mice and discovered that the loss of this ligase causes an increased proliferation and stem cell exhaustion, together with a decreased lymphoid specification in vivo. We observed that the ubiquitin ligase Huwe1 is controlling the expression of N-myc at the level of the most immature stem and progenitor hematopoietic populations, mediating the described effects. Hematopoietic stem cells (HSC) from the bone marrow of transgenic animals carrying a N-myc/mCherry fusion gene were sorted according to N-myc expression (defined by mCherry) into N-myc high and low subpopulations. Each of these 2 populations was subjected to microarray gene expression profiling.

2016-08-20 | E-GEOD-85832 | biostudies-arrayexpress

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