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Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice

ABSTRACT: Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice

PROVIDER: PRJNA636500 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11905109.fastq.gz	Fastqsanger.gz
	SRR11905110.fastq.gz	Fastqsanger.gz
	SRR11905111.fastq.gz	Fastqsanger.gz
	SRR11905112.fastq.gz	Fastqsanger.gz
	SRR11905113.fastq.gz	Fastqsanger.gz

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Tissue signals imprint ILC2 identity with anticipatory function

Project description:Tissue signals imprint ILC2 identity with anticipatory function

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Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice.

Project description:Conventional dendritic cells (cDC) are key activators of naive T cells, and can be targeted in adults to induce adaptive immunity, but in early life are considered under-developed or functionally immature. Here we show that, in early life, when the immune system develops, cDC2 exhibit a dual hematopoietic origin and, like other myeloid and lymphoid cells, develop in waves. Developmentally distinct cDC2 in early life, despite being distinguishable by fate mapping, are transcriptionally and functionally similar. cDC2 in early and adult life, however, are exposed to distinct cytokine environments that shape their transcriptional profile and alter their ability to sense pathogens, secrete cytokines and polarize T cells. We further show that cDC2 in early life, despite being distinct from cDC2 in adult life, are functionally competent and can induce T cell responses. Our results thus highlight the potential of harnessing cDC2 for boosting immunity in early life.

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Layered ontogeny and in situ perinatal priming of tissue ILC2s

Project description:Layered ontogeny and in situ perinatal priming of tissue ILC2s

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Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-11-06 | GSE151595 | GEO

Tissue signals imprint ILC2 identity with anticipatory function [RNA-Seq]

Project description:Tissue signals imprint ILC2 identity with anticipatory function [RNA-Seq]

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Tissue signals imprint ILC2 identity with anticipatory function [single cell RNA-Seq]

Project description:Tissue signals imprint ILC2 identity with anticipatory function [single cell RNA-Seq]

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Distinct waves from the hemogenic endothelium give rise to layered Lymphoid Tissue Inducer cell ontogeny

Project description:Distinct waves from the hemogenic endothelium give rise to layered Lymphoid Tissue Inducer cell ontogeny

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Distinct waves from the hemogenic endothelium give rise to layered Lymphoid Tissue Inducer cell ontogeny [scRNA-seq]

Project description:Distinct waves from the hemogenic endothelium give rise to layered Lymphoid Tissue Inducer cell ontogeny [scRNA-seq]

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Distinct waves from the hemogenic endothelium give rise to layered Lymphoid Tissue Inducer cell ontogeny [bulk RNA-seq]

Project description:LTi cells are part of the ILC family and essential for the formation of secondary lymph nodes within the embryo. This data set contains the analysis of lymphoid tissue (LTi) cell ontogeny, studied by expression profile analysis with RNA bulk sequencing of the populations associated with LTi ontogeny isolated from fetal liver vs. embryonic periphery at embryonic stage E13.5. They indicate a proliferating precursor population mainly in the fetal liver, while the embryonic periphery harbors the definitive lineage.

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Layered ontogeny and in situ perinatal priming of tissue ILC2s

Project description:The perinatal period is a critical window for the distribution of innate tissue-resident immune cells to developing organs. Despite epidemiologic evidence implicating early life environment in risk for allergy, temporally controlled lineage-tracing of ILC2s during this period has not been done. Using complementary fate-mapping approaches and fluorescent reporters of ILC2 activation, we demonstrate that ILC2s appear in multiple organs during late gestation similar to tissue macrophages, but unlike the latter, a majority of peripheral ILC2 pools are generated de novo during a postnatal window. This period was accompanied by systemic ILC2 priming and acquisition of tissue-specific expression profiles. Although perinatal ILC2s are variably replaced with age, the dramatic increases in tissue ILC2s following helminth infection are mediated through local expansion independent of de novo generation by BM hematopoiesis. We provide the first comprehensive temporally controlled fate-mapping of an innate lymphocyte subset with notable nuances as compared to tissue macrophage ontogeny

2019-04-15 | GSE126924 | GEO

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