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Cell state diversity promotes metastasis through heterotypic cluster formation in melanoma [tfap2a/e]

ABSTRACT: Cell state diversity promotes metastasis through heterotypic cluster formation in melanoma [tfap2a/e]

PROVIDER: PRJNA636816 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11909509_1.fastq.gz	Fastqsanger.gz
	SRR11909509_2.fastq.gz	Fastqsanger.gz
	SRR11909510_1.fastq.gz	Fastqsanger.gz
	SRR11909510_2.fastq.gz	Fastqsanger.gz
	SRR11909511_1.fastq.gz	Fastqsanger.gz

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Cell state diversity promotes metastasis through heterotypic cluster formation in melanoma [tfap2a/e]

Project description:We report how the ZMEL1-PRO cell line changes following CRISPR-Cas9 inactivation of tfap2a and tfap2e

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Cell state diversity promotes metastasis through heterotypic cluster formation in melanoma

Project description:Cell state diversity promotes metastasis through heterotypic cluster formation in melanoma

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Cell state diversity promotes metastasis through heterotypic cluster formation in melanoma [2D culture]

Project description:Cell state diversity promotes metastasis through heterotypic cluster formation in melanoma [2D culture]

| PRJNA636817 | ENA

Cell state diversity promotes metastasis through heterotypic cluster formation in melanoma [3D culture]

Project description:Cell state diversity promotes metastasis through heterotypic cluster formation in melanoma [3D culture]

| PRJNA636818 | ENA

Cell state diversity promotes metastasis through heterotypic cluster formation in melanoma [RNA-Seq]

Project description:Cell state diversity promotes metastasis through heterotypic cluster formation in melanoma [RNA-Seq]

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Cell state diversity promotes metastasis through heterotypic cluster formation in melanoma

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-09-15 | GSE151679 | GEO

Cell state diversity promotes metastasis through heterotypic cluster formation in melanoma [RNA-Seq]

Project description:We report single-cell gene expression profiling of the zebrafish melanoma cell lines ZMEL1-PRO and ZMEL1-INV under multiple in vitro and in vivo (zebrafish transplant) conditions

2021-09-15 | GSE152998 | GEO

Cell state diversity promotes metastasis through heterotypic cluster formation in melanoma [3D culture]

Project description:We report the gene expression differences between the zebrafish melanoma cell lines ZMEL1-PRO and ZMEL1-INV

2021-09-15 | GSE151678 | GEO

Cell state diversity promotes metastasis through heterotypic cluster formation in melanoma [2D culture]

Project description:We report the gene expression differences between the zebrafish melanoma cell lines ZMEL1-PRO and ZMEL1-INV

2021-09-15 | GSE151677 | GEO

Cooperation between melanoma cell states promotes metastasis through heterotypic cluster formation.

Project description:Melanomas can have multiple coexisting cell states, including proliferative (PRO) versus invasive (INV) subpopulations that represent a "go or grow" trade-off; however, how these populations interact is poorly understood. Using a combination of zebrafish modeling and analysis of patient samples, we show that INV and PRO cells form spatially structured heterotypic clusters and cooperate in the seeding of metastasis, maintaining cell state heterogeneity. INV cells adhere tightly to each other and form clusters with a rim of PRO cells. Intravital imaging demonstrated cooperation in which INV cells facilitate dissemination of less metastatic PRO cells. We identified the TFAP2 neural crest transcription factor as a master regulator of clustering and PRO/INV states. Isolation of clusters from patients with metastatic melanoma revealed a subset with heterotypic PRO-INV clusters. Our data suggest a framework for the co-existence of these two divergent cell populations, in which heterotypic clusters promote metastasis via cell-cell cooperation.

| S-EPMC8551056 | biostudies-literature

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