Project description:For peloid natural product discovery we have produced 12 spectral libraries, 6 for nighttime sampled peloid (.mgf libraries containing suffix "N") and 6 for daytime sampled peloid (.mgf libraries containing suffix "D" in their name), containing a total of 14,417 individual mass spectra, using a Quadrupole Time-of-Flight (qTOF; 6546 LC/Q-TOF, Agilent, USA) LC-HRMS. In order to identify known natural products, preferably with predetermined biological activity, which would enable us to evaluate Nin peloid mud medicinal property claims, we have used freely available COlleCtion of Open Natural prodUcTs (COCONUT).
2021-11-24 | MSV000088445 | MassIVE
Project description:Identification of natural products against SCLC
Project description:Natural products exhibit potential as candidates for developing multi-target agents for Alzheimer's disease treatment. The aim of this study is to utilize network-based medicine to identify novel natural products for Alzheimer's disease, and investigate their efficacy and mechanisms of action. In this study, we identified (-)-Vestitol and Salviolone as new potential natural products for treating Alzheimer's disease via an Alzheimer's disease-related pathway-gene network. Both natural products improved the cognition of APP/PS1 transgenic mice, reduced Aβ deposition, and lowered soluble toxic Aβ levels in the brain. Notably, a synergistic effect was observed when the two natural products were combined. Transcriptomic analysis and qRT-PCR experiments revealed that the synergistic mechanism of (-)-Vestitol and Salviolone combination is associated with the regulation of a broader range of AD-related pathways and genes, particularly the neuroactive ligand-receptor interaction pathway and calcium signaling pathway.