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RNAseq of livers from WT mice or livers with Rbfox2 knockout fed CD with 30% (w/v) Fructose in the drinking water

ABSTRACT: RNAseq of livers from WT mice or livers with Rbfox2 knockout fed CD with 30% (w/v) Fructose in the drinking water

PROVIDER: PRJNA637091 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11919924_1.fastq.gz	Fastqsanger.gz
	SRR11919924_2.fastq.gz	Fastqsanger.gz
	SRR11919925_1.fastq.gz	Fastqsanger.gz
	SRR11919925_2.fastq.gz	Fastqsanger.gz
	SRR11919926_1.fastq.gz	Fastqsanger.gz

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RNAseq of livers from WT mice or livers with Rbfox2 knockout fed CD with 30% (w/v) Fructose in the drinking water

Project description:Rbfox2 is required for maintaining hepatic metabolic homeostasis. Here we carry out RNAseq to of WT and aged matched litter mate Rbfox2 knockout mice under CD or HFD in order to determine changes in alternative splicing and mRNA expression caused by knockout of this splicing factor in the context of metabolic health and disease.

2022-09-26 | GSE151752 | GEO

RNAseq of livers from WT mice or livers with Rbfox2 knockout fed CD

Project description:Rbfox2 is required for maintaining hepatic metabolic homeostasis, here we carry out RNAseq to of WT and aged matched littermate Rbfox2 knockout mice under high fructose in order to determine changes in alternative splicing and mRNA expression caused by knockout of this splicing factor in this metabolic environment.

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RNAseq of livers from WT mice or livers with Rbfox2 knockout fed CD

Project description:RNAseq of livers from WT mice or livers with Rbfox2 knockout fed CD

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eiCLIP analysis of RBFOX2 in primary mouse hepatocytes

Project description:Rbfox2 is required for maintaining hepatic cholesterol levels under high fructose. Here we carry out an enhanced iCLIP (eiCLIP) protocol in order to determine the targets of Rbfox2 in primary mouse hepatocytes.

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Efffect of a high fructose diet on gene expression in vervet monkey livers.

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Efffect of a high fructose diet on miRNA expression in vervet monkey livers

Project description:High-throughput profiling of miRNA expression in the livers of vervet monkeys fed a high fructose or chow diet. Analysis of differentially expressed miRNAs revealed miR-148a-3p, miR-181a-5p, miR-342-5p and miR-574-5p may have regulatory roles in coordinating changes in hepatic gene expression in response to a high fructose diet.

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Rbfox2 controls autoregulation in RNA binding protein networks

Project description:We generated a global analysis of Rbfox2 splicing regulation combined with a highly specific, single nucleotide-resolution Rbfox2 RNA binding map. We found that Rbfox2 regulates the splicing and expression of many previously unknown targets, and particularly a number of RNA binding proteins (RBPs), by modulating alternative splicing coupled-NMD. Based on our observations of RBP-Rbfox2 co-regulation with a polarity predicted by Rbfox2 binding, we propose a model whereby Rbfox2 tunes autoregulatory splicing events to control RBP expression levels and in turn alter their respective splicing networks. iCLIP for epitope-tagged Rbfox2 and control untagged Rbfox2; RNAseq of control and Rbfox2 knockdown in mouse embryonic stem cells

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Project description:Epidemiologic and animal studies implicate overconsumption of fructose in the development of non-alcoholic fatty liver disease, but the molecular mechanisms underlying fructose-induced chronic liver diseases remains largely unknown. We present evidence supporting the essential function of the lipogenic transcription factor ChREBP in mediating adaptation response to fructose and protecting against fructose-induced hepatotoxicity. High-fructose diet (HFrD) activates hepatic lipogenesis via a ChREBP-dependent manner in wildtype mice, while inducing steatohepatitis in Chrebp-KO mice. In Chrebp-KO mouse livers, HFrD reduces levels of molecular chaperones and activates the CHOP-dependent unfolded protein response, whereas administration of chemical chaperone or Chop shRNA rescues liver injury. Gene expression profiling revealed elevated expression of cholesterol biosynthesis genes in Chrebp-KO livers after HFrD, in parallel with increased abundance of nuclear SREBP2. genes expression were compared between livers of wildtype mice fed 70%-fructose-diet v.s. regular chow, and between livers of Chrebp-/- mice v.s. wildtype mice fed 70%-fructose-diet.

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