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Gene expression data from memory Rictor-/- and WT Tfh and Th1 cells in LCMV acute infection

ABSTRACT: Gene expression data from memory Rictor-/- and WT Tfh and Th1 cells in LCMV acute infection

PROVIDER: PRJNA637301 | ENA |

REPOSITORIES: ENA

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Gene expression data from memory Rictor-/- and WT Tfh and Th1 cells in LCMV acute infection

Project description:Microarray experiments were performed to demonstrate the transcriptome changes due to Rictor deficiency in memory follicular T helper (Tfh) and Type 1 T helper (Th1) cells. These data revealed that the immunological memory formation and persistance associated genes are changed in Rictor-null memory Tfh and Th1 cells, indicating that Rictor is essential for memory CD4 T cell pool.

2021-06-06 | GSE151800 | GEO

Expression data from virus-specific mouse Th1 and Tfh CD4 T cell subsets after LCMV infection

Project description:CD4 T follicular helper (Tfh) cells provide the required signals to B cells for germinal center reactions that are necessary for longlived antibody responses. However, it remains unclear whether there are CD4+ memory T cells committed to the Tfh lineage after antigen clearance. Using adoptive transfer of antigen-specific memory CD4+ subpopulations (based on CXCR5 and Ly6c expression)in the LCMV infection model, we found that there are distinct memory CD4+ T cell populations with commitment to the Tfh and Th1 lineages. Our conclusions are based on gene expression profiles, epigenetic studies and phenotypic and functional analysis. The gene expression profiles of virus-specific CD4 T cell subets at effector and memory stages is presented here. The SMARTA TCR transgenic / adptive transfer system was used to identify and sort subsets of antigen-specific CD4 T cells (based on their expression of Ly6c and CXCR5) elicited after acute infection with LCMV (Arm).

2013-04-22 | E-GEOD-43863 | biostudies-arrayexpress

Expression data from virus-specific mouse Th1 and Tfh CD4 T cell subsets after LCMV infection

2013-04-22 | GSE43863 | GEO

RNA-seq of memory CD4+ Helper T cell subsets (Th1 and Tfh) during LCMV-Armstrong infection

Project description:CD4+ memory T cells play a pivatol role in mediating long-term immunity and therefore are an important target in vaccine development. Multiple functionally distinct helper CD4+ T cell subsets can arise in response to a single invading pathogen, complicating the identification of rare memory CD4+ T cells. Here we found that expression of Id3, an inhibitor of E protein transcription factors, identified a population of cells within both the CD4+ Tfh and Th1 helper lineages that exhibited memory potential in response to secondary infection. Notably, a subset of Th1 memory cells expressing Id3 exhibited enhanced expansion upon response to pathogen, generating both Th1 and Tfh secondary effector cell populations, and displayed enrichment of key molecules associated with memory potential when compared to Id3lo Th1 cells. Thus, Id3 expression serves as an important marker of multipotent memory CD4+ T cells.

2022-07-01 | GSE175740 | GEO

Transcriptome analysis of early differentiating Tfh vs Th1 cells

Project description:Comparison of transcriptome between early Tfh vs. early Th1 cells Blimp-1-YFP LCMV gp specific TCRtg Smarta cells were transferred into B6 mice, which were then infected with LCMV Armstrong. On day 3 after infection, splenocytes were stained to sort Blimp-1-YFP+IL-2Ra+ Th1 cells or Blimp-1-YFP-IL-2Ra- Tfh cells for RNAseq analysis. Contributor: LIAI RNAi center (LIAI)

2015-07-27 | E-GEOD-67334 | biostudies-arrayexpress

RNA-seq of CD4+ Helper T cell subsets (Th1 and Tfh) during LCMV-Armstrong infection

2022-07-01 | GSE175741 | GEO

Gene expression data from LCMV-specific Rictor-/- and WT follicular T helper cells

Project description:Microarray experiments were performed to elucidate the transcriptome changes due to Rictor deficiency in follicular T helper (TFH) cells. These data suggest TFH-lineage associated genes are down-regulated in Rictor-null TFH cells, indicating that Rictor primes TFH differentiation by regulating canonical genes of TFH cells.

2019-04-09 | GSE111536 | GEO

Bulk RNA-sequencing of spleenic LCMV-specific memory TFH cells treated with aICOSL.

Project description:We performed RNA-seq analysis of splenic samples from 8 individual mice sorted for LCMV-specific memory follicular B helper T cells (TFH) with or without aICOSL treatment (4 samples per group).

2019-12-05 | GSE139197 | GEO

RNA-seq of memory CD4+ Helper T cell subsets (Th1 and Tfh) during LCMV-Armstrong infection

Project description:RNA-seq of memory CD4+ Helper T cell subsets (Th1 and Tfh) during LCMV-Armstrong infection

| PRJNA733469 | ENA

Genome-wide maps of chromatin state in naïve CD4+ T cells, WT/EZH2-null TFH and TH1 cells

Project description:ATAC-Seq experiments were performed to elucidate the chromatin state changes among naïve CD4+ T cells, WT follicular helper T (TFH) cells and WT type 1 helper T (TH1) cells Day2 (D2), Day5 (D5), Day8 (D8) post-LCMV-Armstrong infection, as well as EZH2-null (KO) TFH and TH1 at Day8 post-LCMV-infection. The analysis suggested stringent lineage-specific mode of chromatin accessibility in each group, indicating chromatin remodeling is tightly associated with TFH versus TH1 lineage differentiation in response to acute viral infection. Furthermore, the comparison between wild-type and EZH2-null TFH cells showed that less-opening state of certain chromatin accessible region in TFH-differentiation associated genes in the formers, suggesting EZH2 led to permissive chromatin accessibility primarily at specific regions of TFH-associated genes. H3K27me3-ChIP-seq was performed in WT TFH and TH1 cells to confirm the deposition of the histone marks at those loci.

2018-12-31 | GSE120532 | GEO

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