Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptional changes during astrocyte maturation in vivo at single cell resolution

ABSTRACT: Transcriptional changes during astrocyte maturation in vivo at single cell resolution

PROVIDER: PRJNA638662 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR11990636.fastq.gz	Fastqsanger.gz
	SRR11990637.fastq.gz	Fastqsanger.gz
	SRR11990638.fastq.gz	Fastqsanger.gz
	SRR11990639.fastq.gz	Fastqsanger.gz
	SRR11990640.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 12

Similar Datasets

Transcriptional changes during astrocyte maturation in vivo at single cell resolution II

Project description:Transcriptional changes during astrocyte maturation in vivo at single cell resolution II

| PRJNA705355 | ENA

Transcriptional changes during astrocyte maturation in vivo at single cell resolution

Project description:Analysis of gene expression during striatal astrocyte maturation in vivo in mouse by scRNA-Seq

2020-06-11 | GSE152222 | GEO

Transcriptional changes during astrocyte maturation in vivo at single cell resolution II

Project description:Analysis of gene expression during striatal astrocyte maturation in vivo in mouse by scRNA-Seq. This series includes a larger dataset with defined genetic background.

2021-05-19 | GSE167864 | GEO

Chromatin accessibility changes during astrocyte maturation in vivo and in culture

Project description:Analysis of changes in chromatin accessibility during astrocyte differentiation and maturation in vivo and in vitro in mouse, and investigation of transcription factors and extrinsic conditions influencing maturation

2020-06-11 | GSE152219 | GEO

Transcriptional changes during astrocyte maturation in vivo and in culture

Project description:Transcriptional changes during astrocyte maturation in vivo and in culture

| PRJNA638661 | ENA

Transcriptional changes during astrocyte maturation in vivo and in culture

Project description:Analysis of gene expression during astrocyte differentiation and maturation in vivo and in vitro in mouse, and investigation of transcription factors and extrinsic conditions influencing maturation

2020-06-11 | GSE152221 | GEO

Chromatin accessibility changes during astrocyte maturation in vivo and in culture

Project description:Chromatin accessibility changes during astrocyte maturation in vivo and in culture

| PRJNA638660 | ENA

Extensive transcriptional and chromatin changes underlie astrocyte maturation in vivo and in culture

Project description:Extensive transcriptional and chromatin changes underlie astrocyte maturation in vivo and in culture

| PRJNA638651 | ENA

Coordinated Regulation of Cortical Astrocyte Maturation by OLIG1 and OLIG2 through BMP7 Signaling Modulation

Project description:Astrocyte maturation is crucial for brain function, yet the mechanisms regulating this process remain poorly understood. In this study, we identify the bHLH transcription factors Olig1 and Olig2 as essential coordinators of cortical astrocyte maturation. We demonstrate that Olig1 and Olig2 work synergistically to regulate cortical astrocyte maturation by modulating BMP7 expression. Genetic ablation of both Olig1 and Olig2 results in defective astrocyte morphology, including reduced process complexity, and an immature gene expression profile. Single-cell RNA sequencing reveals a shift towards a less mature astrocyte state, marked by elevated levels of HOPX and GFAP, resembling human astrocytes. Mechanistically, Olig1 and Olig2 bind directly to the Bmp7 enhancer, repressing its expression to promote astrocyte maturation. Overexpression of Bmp7 in vivo replicates the astrocyte defects seen in Olig1/2 double mutants, confirming the critical role of BMP7 signaling in this process. These findings provide new insights into the transcriptional and signaling pathways regulating astrocyte development and highlight Olig1 and Olig2 as key regulators of cortical astrocyte maturation, with potential implications for understanding glial dysfunction in neurological diseases.

2024-11-30 | GSE282764 | GEO

Astrocyte-to-astrocyte contact and a positive feedback loop of growth factor signaling regulate astrocyte maturation

Project description:Astrocyte-to-astrocyte contact and a positive feedback loop of growth factor signaling regulate astrocyte maturation

| PRJNA516915 | ENA