Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

CircRNA profilings in gastric cancer

ABSTRACT: CircRNA profilings in gastric cancer

PROVIDER: PRJNA638934 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR11999303_1.fastq.gz	Fastqsanger.gz
	SRR11999303_2.fastq.gz	Fastqsanger.gz
	SRR11999304_1.fastq.gz	Fastqsanger.gz
	SRR11999304_2.fastq.gz	Fastqsanger.gz
	SRR11999305_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 30

Similar Datasets

CircRNA expression profiles for 6 human samples derived from patients with gastric cancer

Project description:Investigation of circRNA expression profile of gastric cancer

2017-01-01 | GSE89143 | GEO

CircRNA expression profiles for 6 human plasma samples derived from patients with gastric cancer

Project description:Investigation of circRNA expression profile of gastric cancer

2017-01-14 | GSE93541 | GEO

CircRNA profilings in gastric cancer

Project description:To identify GC-related RNAs, we used five GC patients’ fresh tumor tissues and paired adjacent non-tumor tissues for RNA sequencing. Differential expressions of circRNAs and mRNAs were then analyzed.

2020-06-12 | GSE152309 | GEO

Tumor-specific circRNAs elicit anti-tumor immune response via encoding cryptic peptides [circRNA-seq]

Project description:By using RNA-seq, we report circRNA or lncRNA profilings from breast cancer tissues and normal tissues.

2023-10-08 | GSE210790 | GEO

Tumor-specific circRNAs elicit anti-tumor immune response via encoding cryptic peptides [circRNA-seq of mouse]

Project description:By using RNA-seq, we report circRNA profilings from B16F10 and melan-a, circRNA profilings from 4T1 and Eph4-ev.

2023-10-08 | GSE210791 | GEO

Transcriptomic analysis of gastric cancer cells in response to stable over-expression of circRNA derived from hnRNPU (circ-hnRNPU)

Project description:Circular RNA (circRNA) is a type of endogenous single-stranded and covalently closed non-coding RNA that plays emerging roles in tumorigenesis and aggressiveness. However, the functions and underlying mechanisms of circRNAs in regulating gastric cancer progression still remain elusive. We identify circ-hnRNPU, a circRNA derived from exons 5, 6, 7 and 8 of heterogeneous nuclear ribonucleoprotein U (hnRNPU), as a tumor suppressor of gastric cancer progression. To investigate the mechanisms underlying the functions of circ-hnRNPU, we employed the Illumina HiSeq X Ten as a discovery platform to analyze the transcriptome profiling changes of human gastric cancer MKN-45 and AGS cells in response to stable over-expression of circ-hnRNPU. The results showed that stable over-expression of circ-hnRNPU led to altered expression of 112 human mRNAs, including 64 up-regulated and 48 down-regulated genes, in both MKN-45 and AGS cells. Furthermore, we validated the RNA-seq results by real-time RT-PCR with high identity. Overall, our results provided fundamental information about the transcriptomic changes in response to circ-hnRNPU over-expression in human gastric cancer cells, and these findings will help us understand the pathogenesis of cancer progression.

2024-11-02 | GSE246847 | GEO

The circular RNA hsa_circ_000780 as a potential molecular diagnostic target for gastric cancer

Project description:The present study aimed to identify a specific circular RNA (circRNA) for early diagnosis of gastric cancer (GC).

2021-09-28 | GSE184882 | GEO

Expression profiles in the progression of the gastric cancer (mRNA+lncRNA+circRNA)

Project description:Expression profiles in the progression of the gastric cancer (mRNA+lncRNA+circRNA)

| PRJNA686069 | ENA

Synthetic circular RNA functions as a miR-21 sponge to suppress gastric carcinoma cell proliferation

Project description:MicroRNA (miRNA) sponges containing miRNA complementary binding sites constitute a potentially useful strategy for miRNA-inhibition therapeutics in cancer patients. Recently, naturally occurring circular RNAs (circRNAs) have been revealed to function as efficient microRNA sponges. We hypothesized that synthetic circRNA sponges targeting oncomiRs could be constructed and used to achieve potentially therapeutic microRNA loss of function. In this study, linear RNA molecules containing five miR-21 binding sites were transcribed in vitro. After dephosphorylation by calf intestinal phosphatase and phosphorylation by T4 polynucleotide kinase, circRNA sponges were circularized using 5’-3’ end ligation by T4 RNA ligase 1. Synthetic circular sponge stability was assayed in the presence of RNase R or fetal bovine serum. Luciferase reporter and cell proliferation assays were performed to assess competitive inhibition of miR-21 activity by circRNA sponges in NCI-N87 gastric cancer cells. Tandem Mass Tag (TMT) labeling proteomics analysis and Western blotting were performed to delineate effects of circRNA sponges on miR-21 downstream targeted proteins. Our experiments revealed that artificial circRNA sponges can be synthesized using enzymatic ligation. These synthetic circRNA sponges are more resistant than their linear RNA counterparts to nuclease degradation in vitro. They effectively suppress the activity of miR-21 on its downstream protein targets, including the important cancer protein DAXX. Finally, they also inhibit gastric cancer cell proliferation. Our results suggest that synthetic circRNA sponges represent a rapid, effective, convenient strategy to achieve loss of miRNA function in vitro, with potential future therapeutic application in vivo.

2018-10-22 | PXD008584 | Pride

RNA Sequencing of six pairs of gastric cancer

Project description:Stomach cancer (GC) remains one of the most prevalent tumors globally, ranking third in terms of cancer-related mortality worldwide. Currently, the prognosis for gastric cancer following radical resection is still suboptimal, primarily due to metastasis. Therefore, it is crucial to explore target therapy as a means to address this issue. Circular RNAs (circRNAs) have emerged as pivotal regulators in the development and progression of cancer and hold promise as biomarkers for diagnosing and prognosticating various cancers. However, the precise mechanism by which circular RNA contributes to metastasis in gastric cancer remains unclear. Our objective is to validate the expression profile of circRNA in gastric cancer and investigate its functional role in metastasis within this context.

2024-07-31 | GSE248612 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data