Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Hnrnpa21 regulates myogenic fate plasticity

ABSTRACT: Hnrnpa21 regulates myogenic fate plasticity

PROVIDER: PRJNA639464 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR12014948_1.fastq.gz	Fastqsanger.gz
	SRR12014948_2.fastq.gz	Fastqsanger.gz
	SRR12014949_1.fastq.gz	Fastqsanger.gz
	SRR12014949_2.fastq.gz	Fastqsanger.gz
	SRR12014950_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 12

Similar Datasets

Hnrnpa21 regulates myogenic fate plasticity

Project description:RNA-binding proteins (RBPs) are essential for skeletal muscle regeneration and RBP dysfunction causes muscle degeneration and neuromuscular disease (NMD). How the timing of RBP function governs the complex cell fate decisions during muscle regeneration is poorly understood. Here, single cell analysis of skeletal muscle regeneration reveals the timing of NMD-associated RBPs expression in muscle progenitors, including a massive upregulation of Hnrnpa2b1 (A2b1). A2b1 promotes muscle progenitor plasticity by regulating the splicing of RNAs expressed at specific times during the trajectory of muscle differentiation. Using RBP-RNA engagement scoring and machine learning, we accurately predict NMD-associated RBP functionality in directing myogenesis. Together our analysis reveals how A2b1 regulates myogenic plasticity and provides a broadly applicable single cell methodology for examining how RBPs influence complex cell fate trajectories.

2020-06-16 | GSE152467 | GEO

Fosl1 regulates mesenchymal GBM plasticity

Project description:Fosl1 regulates mesenchymal GBM plasticity

| PRJNA574145 | ENA

A Pitx2-miRNA pathway modulates cell proliferation in myoblasts and skeletal-muscle satellite cells and promotes their commitment to a myogenic cell fate.

Project description:The acquisition of a proliferating cell status from a quiescent state as well as the shift between proliferation and differentiation are key developmental steps in skeletal-muscle stem cells (satellite cells) to provide proper muscle regeneration. However, how satellite-cell proliferation is regulated, though, is not fully understood. Here, we report that the c-isoform of the transcription factor Pitx2 increases cell proliferation in myoblasts by down-regulating the miRNAs miR-15b, miR-23b, miR-106b, and miR-503. This Pitx2c-miRNA pathway also regulates cell proliferation in early-activated satellite cells, enhancing the Myf5+ satellite cells and thereby promoting their commitment to a myogenic cell fate. This study reveals unknown functions of several miRNAs in myoblast and satellite-cell behaviour and thus may have future applications in regenerative medicine. mirVana microarrays (Ambion) were used to profile microRNA signature at different Pitx2 overexpression conditions, namely two different doses (4 and 8 µg CMV-Pitx2c plasmid, respectively) after 24 hours of transfection in SOL8 skeletal myogenic cells. 20 µg of total RNA was used to hybridize two distinct microRNA microarrays on each condition analyzed.

2015-06-10 | E-GEOD-53943 | biostudies-arrayexpress

Zeb2 regulates myogenic differentiation in pluripotent stem cells

Project description:Zeb2 regulates myogenic differentiation in pluripotent stem cells

| PRJNA616302 | ENA

MST4 kinase regulates B cell function and fate by phosphorylating PRDX1 in inflammatory conditions

Project description:MST4 kinase regulates B cell function and fate by phosphorylating PRDX1 in inflammatory conditions

2024-06-22 | PXD053335 |

A Pitx2-miRNA pathway modulates cell proliferation in myoblasts and skeletal-muscle satellite cells and promotes their commitment to a myogenic cell fate

2015-06-10 | GSE53943 | GEO

De novo DNA methylation by DNA Methyltransferase 3a controls early effector CD8+ T cell fate decisions following activation

Project description:DNMT3a is a de novo DNA methyltransferase expressed robustly after T cell activation that regulates plasticity of CD4+ T cell cytokine expression. Here we show that DNMT3a is critical for directing early CD8+ T cell effector and memory fate decisions. While effector function of DNMT3a knockout T cells is normal, they develop more memory precursor and fewer terminal effector cells in a T cell intrinsic manner compared to wild-type animals. Rather than increasing plasticity of differentiated effector CD8+ T cells, loss of DNMT3a biases differentiation of early effector cells into memory precursor cells. This is attributed in part to ineffective repression of Tcf1 expression in knockout T cells, as DNMT3a localizes to the Tcf7 promoter and catalyzes its de novo methylation in early effector WT CD8+ T cells. This data identifies DNMT3a as a crucial regulator of CD8+ early effector cell differentiation and effector versus memory fate decisions. Examination of global genomic DNA methylation by MBD-seq in naÃ¯ve CD8 T cells and CD8 T cells 8 days post Vaccinia-Ova infection, comparing OT1 TCR-Tg CD8 T cells isolated from WT and T cell conditional DNMT3a KO mice.

2016-08-20 | E-GEOD-85823 | biostudies-arrayexpress

An unbalanced BMP-biomechanical niche reveals the plasticity of the mammalian myogenic lineage

Project description:An unbalanced BMP-biomechanical niche reveals the plasticity of the mammalian myogenic lineage

| PRJNA668349 | ENA

SMARCA4 regulates BRD4 nuclear distribution in cellular plasticity

Project description:SMARCA4 regulates BRD4 nuclear distribution in cellular plasticity

| PRJNA1141555 | ENA

Schwann cell plasticity regulates neuroblastic tumor cell differentiation

Project description:Schwann cell plasticity regulates neuroblastic tumor cell differentiation

| PRJNA615860 | ENA