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Transcriptome analysis of human aortic endothelial cells (HAECs) with KLF11 knockdown

ABSTRACT: Transcriptome analysis of human aortic endothelial cells (HAECs) with KLF11 knockdown

PROVIDER: PRJNA639465 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12014954_1.fastq.gz	Fastqsanger.gz
	SRR12014954_2.fastq.gz	Fastqsanger.gz
	SRR12014955_1.fastq.gz	Fastqsanger.gz
	SRR12014955_2.fastq.gz	Fastqsanger.gz
	SRR12014956_1.fastq.gz	Fastqsanger.gz

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Transcriptome analysis of human aortic endothelial cells (HAECs) with KLF11 knockdown

Project description:HAECs were infected with Ad-shlacZ (10MOI) or Ad-shKLF11 (10MOI) for 48 hours and harvest for RNA-sequencing

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Transcription profiling of human aortic endothelial cells with miR-10a knock down

Project description:This study investigates the miR-10a-mediated transcriptome in human aortic endothelial cells (HAECs). The EC transcriptome was profiled in miR-10a knockdown HAECs. Specifically, small amounts of EC RNA were isolated from control cells and miR-10 knockdown cells expressing miRNA inhibitor control (Dharmacon) and miR-10a inhibitors (Dharmacon), respectively . Eight 2-channel assays comparing knockdown to control were performed using the Agilent Whole Human Genome Microarray 4x44K [G4112F].

2010-07-01 | E-CBIL-45 | biostudies-arrayexpress

ChIP-seq of H3K27acethylation of human aortic endothelial cells (HAECs) treated with Cobalt chloride (CoCl2)

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RNA-Seq of human aortic endothelial cells with lysophosphatidylinositol against untreated controls

Project description:Vascular Innate immune cells, such as macrophages, elicit long-term T cell-, and B cell- immune responses, by expressing danger-associated molecular pattern (DAMP) receptors, T cell co-stimulation receptors and presenting antigens to the adaptive system through major histocompatibility complex (MHC)-II. Here, we investigated whether human aortic endothelial cells (HAECs) could also be “transdifferentiated” into innate immune cells after treatment of hyperlipidemia-upregulated DAMP molecules, lysophosphatidylinositol (LPI). HAECs were treated with vehicle control or lysophosphatidylinositol (16:0) (10µM) for 18 hours.

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Transcriptional profiling of trimethylamine N-oxide (TMAO) stimulated human aortic endothelial cells (HAECs)

Project description:Transcriptional profiling of trimethylamine N-oxide (TMAO) stimulated human aortic endothelial cells (HAECs)

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Transcriptome analysis of human aortic valvular endothelial cells with PPARG knockdown and oxLDL treatment.

Project description:We isolated and cultured human aortic valvular endothelial cells from patients, and performed RNA sequencing of human aortic valvular endothelial cells transfected with siRNA targeting PPARG or negative control siRNA and treated with or without oxLDL.

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Transcriptional profiling of trimethylamine N-oxide (TMAO) stimulated human aortic endothelial cells (HAECs)

Project description:Purpose: The goals of this study were to identify preferential gene expression signatures that are unique to HAECs stimulated with the uremic toxin, TMAO, to accelerate vascular inflammation associated with chronic kidney diseases. Methods and results: HAECs were treated with TMAO (600 µM) for 18 hours, and RNAs were collected to generate mRNA transcription profiles. Transcriptional profiling revealed a unique TMAO stimulated HAECs relative to a non-stimulated control HAECs. Conclusion: Our study represents the first detailed analysis of TMAO treated HAECs transcriptome.

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Project description:We report the first deep RNASeq time-series dataset (n=96 samples) of human aortic endothelial cells (HAECs) following exposure to normal (NG) and high glucose (HG) conditions over a time course from baseline to 24 hours (0, 0.5, 1, 4, 8 and 24 hours). We identify rapid and transient transcriptomic changes, alteration of molecular networks, and document temporal transcriptional dynamics of in HAECs.

2022-05-21 | GSE203284 | GEO

Isoforms of SEMA3E-containing supernatant treated gene expression in human aortic endothelial cells

Project description:The expression of SEMA3E isoforms changes in mouse circulation with type 1 diabetes. The alterations in the transcriptional profiles of human aortic endothelial cells (HAECs) in response to PCS1 (Processing consensus sequences)-cleaved SEMA3E and PCS1-uncleaved SEMA3E were examined.

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