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ABSTRACT: Intestinal microbiome influenced by titanium dioxide nanoparticle

PROVIDER: PRJNA640595 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12053800_1.fastq.gz	Fastqsanger.gz
	SRR12053800_2.fastq.gz	Fastqsanger.gz
	SRR12053801_1.fastq.gz	Fastqsanger.gz
	SRR12053801_2.fastq.gz	Fastqsanger.gz
	SRR12053802_1.fastq.gz	Fastqsanger.gz

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Project description:Reportedly, titanium dioxide nanoparticle exposure during pregnancy can affect the development of the central nervous system in mouse offspring; however, the underlying mechanism remains unknown. We investigated the impact of prenatal dioxide nanoparticle exposure on mRNA expression patterns in the brains of neonatal mice. Pregnant C57BL/6J mice were intratracheally administered a dioxide nanoparticle suspension (100 ug/mouse) on gestational day 10.5, and brains were collected from male and female offspring at day 1 postpartum. Total RNA was obtained, and mRNA expression profiles were comprehensively assessed using microarray analysis. The results showed 88 and 89 genes were upregulated (≥ 1.5-fold) accompanied by demethylation of CpG islands, whereas 13 and 33 genes were downregulated (≤ 0.67-fold) accompanied by demethylation of CpG islands in male and female offspring mice, respectively. Gene Set Enrichment Analysis (GSEA) revealed that these genes were enriched in gene ontology terms related to the regulation of transcription factors, cell proliferation, and organism development. Additionally, MeSH terms related to stem cells and morphogenesis were enriched.

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