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Chromatin regulates expression of small RNAs to help maintain transposon methylome homeostasis in Arabidopsis

ABSTRACT: Chromatin regulates expression of small RNAs to help maintain transposon methylome homeostasis in Arabidopsis

PROVIDER: PRJNA641096 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12067230.fastq.gz	Fastqsanger.gz
	SRR12067231.fastq.gz	Fastqsanger.gz
	SRR12067232.fastq.gz	Fastqsanger.gz
	SRR12067233.fastq.gz	Fastqsanger.gz
	SRR12067234.fastq.gz	Fastqsanger.gz

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Chromatin regulates expression of small RNAs to help maintain transposon methylome homeostasis in Arabidopsis.

Project description:BACKGROUND:Eukaryotic genomes are partitioned into euchromatic and heterochromatic domains to regulate gene expression and other fundamental cellular processes. However, chromatin is dynamic during growth and development and must be properly re-established after its decondensation. Small interfering RNAs (siRNAs) promote heterochromatin formation, but little is known about how chromatin regulates siRNA expression. RESULTS:We demonstrate that thousands of transposable elements (TEs) produce exceptionally high levels of siRNAs in Arabidopsis thaliana embryos. TEs generate siRNAs throughout embryogenesis according to two distinct patterns depending on whether they are located in euchromatic or heterochromatic regions of the genome. siRNA precursors are transcribed in embryos, and siRNAs are required to direct the re-establishment of DNA methylation on TEs from which they are derived in the new generation. Decondensed chromatin also permits the production of 24-nt siRNAs from heterochromatic TEs during post-embryogenesis, and siRNA production from bipartite-classified TEs is controlled by their chromatin states. CONCLUSIONS:Decondensation of heterochromatin in response to developmental, and perhaps environmental, cues promotes the transcription and function of siRNAs in plants. Our results indicate that chromatin-mediated siRNA transcription provides a cell-autonomous homeostatic control mechanism to help reconstitute pre-existing chromatin states during growth and development including those that ensure silencing of TEs in the future germ line.

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Chromatin regulates expression of small RNAs to help maintain transposon methylome homeostasis in Arabidopsis

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