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CD4+ T cells Reject Benign Melanocytic Nevi

ABSTRACT: CD4+ T cells Reject Benign Melanocytic Nevi

PROVIDER: PRJNA642297 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12102188_1.fastq.gz	Fastqsanger.gz
	SRR12102188_2.fastq.gz	Fastqsanger.gz
	SRR12102189_1.fastq.gz	Fastqsanger.gz
	SRR12102189_2.fastq.gz	Fastqsanger.gz
	SRR12102190_1.fastq.gz	Fastqsanger.gz

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CD4+ T cells Reject Benign Melanocytic Nevi

Project description:Human CD4+ T cells mediate spontaneous rejection of acquired benign melanocytic nevi, in the majority of cases, through a break in peripheral tolerance. For the remaining cases, nevi remain stable and do not progress to malignancy. In this experiment, we compared gene expression of post-transplant rejected nevi to stable nevi in order to better characterize their transcriptional profiles.

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Project description:Acquired melanocytic nevi grow and persist in a stable form into adulthood. Using genome-wide methylation profiling, we evaluated 32 histopathologically confirmed, and dermoscopically characterized nevi, with matched adjacent skin, to identify key epigenetic regulatory mechanisms involved in nevogenesis. Benign (n=13; 69% globular and 31% non-specific dermoscopic pattern) and dysplastic (n=19; 95% reticular/nonspecific dermoscopic pattern) nevi were dissimilar with only two shared differentially methylated (DM) loci. Relative to adjacent skin, benign nevi demonstrated an increase in both genome-scale methylation and methylation of Alu/LINE-1 retrotransposable elements, a marker of genomic stability, as well as global methylation. In contrast, dysplastic nevi showed evidence for genomic instability via hypomethylation of Alu/LINE-1. The difference in methylation between benign and dysplastic nevi was statistically significant for Alu (P = 0.00019) and LINE-1 (P = 0.000035) retrotransposable elements. Using dermoscopic classifications, reticular/nonspecific nevi had 59,572 CpG DM loci (Q < 0.05), whereas globular nevi had non-significant DM loci. The relative activity of reticular/non-specific nevi was evidenced by 50,720 hypomethylated loci being enriched for accessible chromatin, and 8,852 hypermethylated loci strongly enriched, for example, marks of active gene promoters, which suggests that gain of DNA methylation observed in these nevus types plays a role in gene regulation.

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Rejection of benign melanocytic nevi by nevus-resident CD4+ T cells.

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| S-EPMC8221625 | biostudies-literature

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