Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

CD4+ T cells Reject Benign Melanocytic Nevi

ABSTRACT: CD4+ T cells Reject Benign Melanocytic Nevi

PROVIDER: PRJNA642297 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR12102188_1.fastq.gz	Fastqsanger.gz
	SRR12102188_2.fastq.gz	Fastqsanger.gz
	SRR12102189_1.fastq.gz	Fastqsanger.gz
	SRR12102189_2.fastq.gz	Fastqsanger.gz
	SRR12102190_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 24

Similar Datasets

CD4+ T cells Reject Benign Melanocytic Nevi

Project description:Human CD4+ T cells mediate spontaneous rejection of acquired benign melanocytic nevi, in the majority of cases, through a break in peripheral tolerance. For the remaining cases, nevi remain stable and do not progress to malignancy. In this experiment, we compared gene expression of post-transplant rejected nevi to stable nevi in order to better characterize their transcriptional profiles.

2021-07-08 | GSE153399 | GEO

Deconvoluted methylation profiles discriminate between closely related melanocytic nevi

Project description:Congenital melanocytic nevi (CMN) and common acquired melanocytic nevi (AMN) are skin conditions that result from an excess of melanocytes arising during fetal development or detected postnatally. Appropriately weighted whole-genome methylation analysis can be used as a basis for further research in dermatopathology and, in this application, provides new insights into nevus biology.

2024-06-17 | GSE268769 | GEO

Progressive immune activation and negative immunoregulation from common melanocytic nevi to dysplastic nevi to melanoma

Project description:The purpose of this study was to comprehensively study and compare the molecular gene expression profiles of common melanocytic nevi (GSE53223), dysplastic nevi (GSE53223), and primary melanoma.

2018-10-25 | GSE114445 | GEO

microRNAs Restrain Proliferation in BRAFV600E Melanocytic Nevi [RNA-Seq]

Project description:We conducted small RNA sequencing on low passage human melanocytes derived from melanocytic nevi and normal skin.

2021-05-13 | GSE174372 | GEO

microRNAs Restrain Proliferation in BRAFV600E Melanocytic Nevi [miRNA-Seq]

Project description:We conducted small RNA sequencing on low passage human melanocytes derived from melanocytic nevi and normal skin.

2021-05-13 | GSE174371 | GEO

Genome-scale DNA methylation analysis identifies repeat element alterations that modulate the genomic stability of melanocytic nevi

Project description:Acquired melanocytic nevi grow and persist in a stable form into adulthood. Using genome-wide methylation profiling, we evaluated 32 histopathologically confirmed, and dermoscopically characterized nevi, with matched adjacent skin, to identify key epigenetic regulatory mechanisms involved in nevogenesis. Benign (n=13; 69% globular and 31% non-specific dermoscopic pattern) and dysplastic (n=19; 95% reticular/nonspecific dermoscopic pattern) nevi were dissimilar with only two shared differentially methylated (DM) loci. Relative to adjacent skin, benign nevi demonstrated an increase in both genome-scale methylation and methylation of Alu/LINE-1 retrotransposable elements, a marker of genomic stability, as well as global methylation. In contrast, dysplastic nevi showed evidence for genomic instability via hypomethylation of Alu/LINE-1. The difference in methylation between benign and dysplastic nevi was statistically significant for Alu (P = 0.00019) and LINE-1 (P = 0.000035) retrotransposable elements. Using dermoscopic classifications, reticular/nonspecific nevi had 59,572 CpG DM loci (Q < 0.05), whereas globular nevi had non-significant DM loci. The relative activity of reticular/non-specific nevi was evidenced by 50,720 hypomethylated loci being enriched for accessible chromatin, and 8,852 hypermethylated loci strongly enriched, for example, marks of active gene promoters, which suggests that gain of DNA methylation observed in these nevus types plays a role in gene regulation.

2021-12-07 | GSE188593 | GEO

microRNAs Restrain Proliferation in BRAFV600E Melanocytic Nevi [miRNA-Seq, RNA-Seq]

Project description:We conducted small RNA sequencing on low passage human melanocytes derived from melanocytic nevi and normal skin.

2020-05-22 | GSE150849 | GEO

microRNAs Restrain Proliferation in BRAFV600E Melanocytic Nevi

Project description:microRNAs Restrain Proliferation in BRAFV600E Melanocytic Nevi

| PRJNA729639 | ENA

Transcriptome analysis of human hairy melanocytic nevi

Project description:Transcriptome analysis of human hairy melanocytic nevi

| PRJNA445288 | ENA

Rejection of benign melanocytic nevi by nevus-resident CD4+ T cells.

Project description:Melanoma and melanocytic nevi harbor shared lineage-specific antigens and oncogenic mutations. Yet, the relationship between the immune system and melanocytic nevi is unclear. Using a patient-derived xenograft (PDX) model, we found that 81.8% of the transplanted nevi underwent spontaneous regression, while peripheral skin remained intact. Nevus-resident CD4+ T helper 1 cells, which exhibited a massive clonal expansion to melanocyte-specific antigens, were responsible for nevus rejection. Boosting regulatory T cell suppressive function with low-dose exogenous human interleukin-2 injection or treatment with a human leukocyte antigen (HLA) class II-blocking antibody prevented nevus rejection. Notably, mice with rejected nevus PDXs were protected from melanoma tumor growth. We detected a parallel CD4+ T cell-dominant immunity in clinically regressing melanocytic nevi. These findings reveal a mechanistic explanation for spontaneous nevus regression in humans and posit the activation of nevus-resident CD4+ effector T cells as a novel strategy for melanoma immunoprevention and treatment.

| S-EPMC8221625 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data