Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

An inter-dependent network of enhancers regulates INK4a/ARF locus

ABSTRACT: An inter-dependent network of enhancers regulates INK4a/ARF locus

PROVIDER: PRJNA642363 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR12102811.fastq.gz	Fastqsanger.gz
	SRR12102812.fastq.gz	Fastqsanger.gz
	SRR12102813.fastq.gz	Fastqsanger.gz
	SRR12102814.fastq.gz	Fastqsanger.gz
	SRR12102815.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 8

Similar Datasets

An inter-dependent network of enhancers regulates INK4a/ARF locus

Project description:By functionally dissecting densest enhancer cluster in the gene desert at 9P21 locus, we identified a non-redundant inter-dependent enhancer network that functions over long distances, the perturbation in any enhancer in the network results in the complete collapse of entire enhancer cluster and target genes activity. The enhancer network can be targeted to regulate INK4a/ARF locus in associated pathophysiologies and cancers.

2021-04-19 | GSE153410 | GEO

Transcription profiling of mouse neural stem cells derived from Ink4a/Arf-/- vs Bmi1-/-;Ink4a/Arf-/- mutants

Project description:Comparison of gene expression of Ink4a/Arf-/- vs Bmi1-/-;Ink4a/Arf-/- subventricular zone (SVZ) derived mouse neural stem cells (NSC) on Laminin (LM) and Fibronectin (FN) substrates.

2009-02-25 | E-NCMF-22 | biostudies-arrayexpress

Expression data from Bmi1-overexpressing Ink4a-Arf-null hepatoblasts

Project description:Forced expression of Bmi1 accelerated the self-renewal of hepatic stem/progenitor cells and eventually induced their transformation in an in vivo transplant model. The Ink4a/Arf locus, which encodes a cyclin-dependent kinase inhibitor, p16Ink4a, and a tumor suppressor, p19Arf, is a pivotal target of Bmi1. Therefore, it would be of importance to understand the contribution of the Ink4a/Arf locus to Bmi1 oncogenic functions in cancer and search for as-yet-unknown Bmi1 target genes other than Ink4a/Arf. We used microarrays to explore novel candidate downstream targets for Bmi1 in hepatic stem/progenitor cells

2009-08-01 | GSE17462 | GEO

Transcription profiling of pre-injected brain cells from female INK4a/ARF knock-out, BMI1 INK4a/ARF knock-out mice and tumor cells derived from these mice

Project description:Comparison of gene expression profiles between pre-injected brain cells from female INK4a/ARF knock-out, BMI1 INK4a/ARF knock-out mice and tumor cells derived thereof.

2007-11-15 | E-NCMF-4 | biostudies-arrayexpress

Mll3 suppresses tumorigenesis by activating the Ink4a/Arf locus

Project description:Mll3 suppresses tumorigenesis by activating the Ink4a/Arf locus

| PRJNA336025 | ENA

shGFP- and shQk-transduced Ink4a/Arf-/- Pten-/- primary mouse astrocytes

Project description:Identify potential QK-regulated mRNAs and linked pathways by comparing the transcriptional profiles of shGFP- and shQK-transduced Ink4a/Arf-/- Pten-/- primary mouse astrocytes Ink4a/Arf-/- Pten-/- primary mouse astrocytes infected with shQk-1, shQk-2 and infected with shGFP as control

2009-12-30 | E-GEOD-19687 | biostudies-arrayexpress

microRNA expression of Ink4a/Arf-/- Pten-/- mouse astrocytes

Project description:To identify QK-modulated microRNAs exhibiting a >1.5-fold change across all three cell model systems: human GBM cell lines, U87 and Hs683, and Ink4a/Arf-/- Pten-/- mouse astrocytes

2009-12-30 | GSE19692 | GEO

The Ink4a/Arf locus operates as a regulator of the circadian clock modulating RAS activity

Project description:Upon perturbations by RAS and by shBMAL, differential effects on the circadian phenotype were observed in wild type and Ink4a/Arf knockout MEFs which could be reproduced by modelling simulations and correlated with opposing cell cycle fate decisions.

2017-12-08 | E-MTAB-5943 | biostudies-arrayexpress

shGFP- and shQk-transduced Ink4a/Arf-/- Pten-/- primary mouse astrocytes

Project description:Identify potential QK-regulated mRNAs and linked pathways by comparing the transcriptional profiles of shGFP- and shQK-transduced Ink4a/Arf-/- Pten-/- primary mouse astrocytes

2009-12-30 | GSE19687 | GEO

Transcription profiling of mouse Bmi1-overexpressing Ink4a-Arf-null hepatoblasts

2009-08-07 | E-GEOD-17462 | biostudies-arrayexpress