Project description:Analyzed sequencing data from bone marrow samples taken from patients enrolled on ENSIGN or ELIANA clinical trials prior to infusion of CART19.
Project description:RATIONALE: Radiation therapy uses high-energy x-rays to damage cancer cells. Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining chemotherapy with bone marrow transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more tumor cells.
PURPOSE: Phase II trial to study the effectiveness of bone marrow transplantation in treating patients who have hematologic cancer.
Project description:The single cell and bulk expression profiles of early pro T-cell progenitors generated from purified mouse bone marrow, cultured on different stromal cell systems
Project description:miRNA expression in a patient with AML comparing with pooled CD34 hematopoietic progenitor cells from 5 healthy volunteers RNA from bone marrow of a patient with AML with more than 90% blast and RNA pooled from 5 volunteers with CD34+ cells selected by automacs from bone marrow
Project description:Single-cell RNA-seq analysis of primary human bone marrow immune populations isolated from B-ALL patient samples (matched diagnosis, remission and relapse), and healthy bone marrow donor samples.
Project description:Bulk mRNA from mouse bone marrow-derived dendritic cells (BMDCs) was sequenced. Samples were obtained from Wild Type (C57BL/6J) mice, or mice with GNAS knocked out specifically in CD11c +ve cells.