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Longevity strategies in response to light in the reef coral Stylophora pistillata

ABSTRACT: Longevity strategies in response to light in the reef coral Stylophora pistillata

PROVIDER: PRJNA643777 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12135881.fastq.gz	Fastqsanger.gz
	SRR12135882.fastq.gz	Fastqsanger.gz
	SRR12135883.fastq.gz	Fastqsanger.gz
	SRR12135884.fastq.gz	Fastqsanger.gz
	SRR12135885.fastq.gz	Fastqsanger.gz

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Longevity strategies in response to light in the reef coral Stylophora pistillata

Project description:Aging is a multifactorial process that results in progressive loss of regenerative capacity and tissue function while simultaneously favoring the development of a large array of age-related diseases. Evidence suggests that the accumulation of senescent cells in tissue promotes both normal and pathological aging. Oxic stress is a key driver of cellular senescence. Because symbiotic long-lived reef corals experience daily hyperoxic and hypoxic transitions, we hypothesized that these long-lived animals have developed specific longevity strategies in response to light. We analyzed transcriptome variation in the reef coral Stylophora pistillata during the day–night cycle and revealed a signature of the FoxO longevity pathway. We confirmed this pathway by immunofluorescence using antibodies against coral FoxO to demonstrate its nuclear translocation. Among genes that were specifically up- or downregulated on exposure to light, human orthologs of two “light-up” genes (HEY1 and LONF3) exhibited anti-senescence properties in primary human fibroblasts. Therefore, these genes are interesting candidates for counteracting skin aging. We propose a large screen for other light-up genes and an investigation of the biological response of reef corals to light (e.g., metabolic switching) to elucidate these processes and identify effective interventions for promoting healthy aging in humans.

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