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Transcriptome profile of INS-1E Ctrl and DKO cells

ABSTRACT: Transcriptome profile of INS-1E Ctrl and DKO cells

PROVIDER: PRJNA643780 | ENA |

REPOSITORIES: ENA

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Transcriptome profile of INS-1E Ctrl and hTFEB OE cells

Project description:Transcriptome profile of INS-1E Ctrl and hTFEB OE cells

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Transcriptome profile of INS-1E Ctrl and DKO cells

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Project description:By using His6-tagged recombinant human secretagogin in the presence of Ca2+ (100 µM), we precipitated putative interacting partners from INS-1E cells and identified their amino acid sequences by mass spectrometry. We detected canonical interacting proteins participating in vesicle-mediated transport, exocytosis and cytoskeletal organization. Besides, we captured proteins controlling protein folding and (de-)ubiquitination. Our data support that secretagogin modulates protein folding and degradation through protein-protein interactions and interacts with USP9X in β cells to control cell survival.

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Expression data from rat INS-1E cells

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