Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

8-week WT or Ftsj1 KO mouse brain total mRNAs and ribosome-contained mRNAs

ABSTRACT: 8-week WT or Ftsj1 KO mouse brain total mRNAs and ribosome-contained mRNAs

PROVIDER: PRJNA643980 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR12143646.fastq.gz	Fastqsanger.gz
	SRR12143647.fastq.gz	Fastqsanger.gz
	SRR12143648.fastq.gz	Fastqsanger.gz
	SRR12143649.fastq.gz	Fastqsanger.gz
	SRR12143650.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 18

Similar Datasets

8-week WT or Ftsj1 KO mouse brain total mRNAs and ribosome-contained mRNAs

Project description:8-week mouse brain ribosome-contained mRNAs and total mRNAs were collected and sequenced.

2021-03-31 | GSE153756 | GEO

P0.5 WT or Ftsj1 KO mouse brain or liver total mRNA or ribosome-contained mRNA

Project description:P0.5 WT or Ftsj1 KO mouse brain or liver ribosome-contained mRNAs or total mRNAs, and were sequenced using MiSeq and HiSeq.

2021-03-31 | GSE153797 | GEO

P0.5 WT or Ftsj1 KO mouse brain or liver total mRNA or ribosome-contained mRNA

Project description:P0.5 WT or Ftsj1 KO mouse brain or liver total mRNA or ribosome-contained mRNA

| PRJNA644116 | ENA

8-week WT or Ftsj1 KO mouse brain tRNA and tRF MiSeq

Project description:8-week brain total tRNA, total tRNA fragments (tRFs), and ribosome-contained tRNAs were sequenced using MiSeq.

2021-03-31 | GSE153757 | GEO

8-week WT or Ftsj1 KO mouse brain tRNA and tRF MiSeq

Project description:8-week WT or Ftsj1 KO mouse brain tRNA and tRF MiSeq

| PRJNA643981 | ENA

Next Generation Sequencing identifies differential genes regulated by FTSJ1 overexpression

Project description:We report the application of RNA-sequencing for high-throughput profiling of transcriptomes in PC9 cells transfected with stably expressed FTSJ1.

2020-05-19 | GSE146604 | GEO

The ribose methylation enzyme FTSJ1 has a conserved role in neuron morphology and learning performance

Project description:FTSJ1 is a conserved human 2’-O-methyltransferase (Nm-MTase) that modifies several transfer RNAs (tRNAs) at position 32 and the wobble position 34 in the AntiCodon Loop (ACL). Its loss of function has been linked to Non-Syndromic X-Linked Intellectual Disability (NSXLID), and more recently to cancers. However, the molecular mechanisms underlying these pathologies are currently unclear. Here we report a novel FTSJ1 pathogenic variant from a NSXLID patient. Using blood cells derived from this patient and other affected individuals carrying FTSJ1 mutations, we performed an unbiased and comprehensive RiboMethSeq analysis to map the ribose methylation (Nm) on all tRNAs and identify novel targets. In addition, we performed a transcriptome analysis in these cells and found that several genes previously associated with intellectual disability and cancers were deregulated. We also found changes in the miRNA population that suggest potential cross-regulation of some miRNAs with these key mRNA targets. Finally, we show that differentiation of FTSJ1-depleted human neuronal progenitor cells (NPC) into neurons displays long and thin spine neurites compared to control cells. These defects are also observed in Drosophila and are associated with long term memory deficit in this organism. Altogether, our study adds insight into FTSJ1 pathologies in human by the identification of novel FTSJ1 targets and the defect in neuron morphology.

2023-01-06 | GSE179384 | GEO

WT or Ftsj1 KO mouse brain

Project description:WT or Ftsj1 KO mouse brain

| PRJNA643976 | ENA

Plastic remains contained soil sample

Project description:Plastic remains contained soil sample Metagenome

| PRJNA764827 | ENA

FTSJ1 patients RNASeq

Project description:RNASeq: FTSJ1 tRNA Nm-MTase: new human targets and role in the regulation of brain-specific genes

| PRJEB46399 | ENA