Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Lionheart LincRNA Alleviates Cardiac Systolic Dysfunction under Pressure Overload

ABSTRACT: Lionheart LincRNA Alleviates Cardiac Systolic Dysfunction under Pressure Overload

PROVIDER: PRJNA644194 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Lionheart LincRNA Alleviates Cardiac Systolic Dysfunction under Pressure Overload

Project description:to screen upregulated lincRNAs in pressure overloaded hearts, we conducted microarray analysis

2020-08-19 | GSE153814 | GEO

Lionheart LincRNA alleviates cardiac systolic dysfunction under pressure overload.

Project description:Recent high-throughput approaches have revealed a vast number of transcripts with unknown functions. Many of these transcripts are long noncoding RNAs (lncRNAs), and intergenic region-derived lncRNAs are classified as long intergenic noncoding RNAs (lincRNAs). Although Myosin heavy chain 6 (Myh6) encoding primary contractile protein is down-regulated in stressed hearts, the underlying mechanisms are not fully clarified especially in terms of lincRNAs. Here, we screen upregulated lincRNAs in pressure overloaded hearts and identify a muscle-abundant lincRNA termed Lionheart. Compared with controls, deletion of the Lionheart in mice leads to decreased systolic function and a reduction in MYH6 protein levels following pressure overload. We reveal decreased MYH6 results from an interaction between Lionheart and Purine-rich element-binding protein A after pressure overload. Furthermore, human LIONHEART levels in left ventricular biopsy specimens positively correlate with cardiac systolic function. Our results demonstrate Lionheart plays a pivotal role in cardiac remodeling via regulation of MYH6.

| S-EPMC7426859 | biostudies-literature

Loss of talin in cardiac fibroblasts results in augmented ventricular cardiomyocyte hypertrophy in response to pressure overload

Project description:To look at the affect of talins in cardiac fibroblasts (CF), we subjected Tln2-null and Tln2-null; Tln1-specific CF knockout mice to AngII stimulation for 8 weeks to induce pressure overload injury. We found that Tln2-null; Tln1-specific CF knockout mice had increaed cardiomyocyte hypertrophy and systolic blood pressure, with not change in intersitial fibrosis.

2022-04-27 | GSE189323 | GEO

Systolic Blood Pressure Intervention Trial (SPRINT-BioLINCC)

Project description:Systolic Blood Pressure Intervention Trial (SPRINT-BioLINCC)

| PRJNA1047942 | ENA

Systolic Blood Pressure Intervention Trial (SPRINT-BioLINCC)

Project description:Systolic Blood Pressure Intervention Trial (SPRINT-BioLINCC)

| PRJNA1047941 | ENA

Systolic Blood Pressure Intervention Trial (SPRINT-Imaging)

Project description:Systolic Blood Pressure Intervention Trial (SPRINT-Imaging)

| PRJNA1079434 | ENA

Myocardial gene expression in response to pressure overload

Project description:Myocardial deletion of klf4 sensitizes mouse to pressure overload. In order to gain a better understanding of molecular mechanisms of such alterations, we profiled gene expression before and after 3-day of pressure overload (induced by transverse aortic constriction -TAC) in the hearts from MHC-cre (Cre) control and MHC-cre-klf4-deficient (KO) mice. 10wk old male mice was subjected to transverse aortic constriction (TAC) to induce pressure overload or sham operation as control group. After 3 days, heart was removed and total RNA was extracted from apex and subjected for array analysis. Four animals in each group.

2015-07-01 | E-GEOD-61177 | biostudies-arrayexpress

Pressure-Overload Induced Cardiac Hypertrophy

Project description:Aortic banding is an excellent model system to evaluate the process of development of left ventricular hypertrophy in response to hemodynamic stress. The Affymetrix GeneChip MgU74Av1 was used to analyze expression profiles of mice at different time points after surgical intervention for pressure-overload induced hypertrophy. More information about this model may be obtained at http://cardiogenomics.med.harvard.edu/groups/proj1/pages/band_home.html Keywords = Pressure overload, cardiac hypertrophy Keywords: time-course

2002-07-30 | GSE76 | GEO

Pressure overload cardiac hypertrophy

Project description:Expression profiling of hearts from FVB males subjected to cardiac pressure overload by transverse aortic constriction (TAC). TAC performed on 8-10 weeks month old males and females. Hearts examined 30 weeks after surgery. Keywords: ordered

2005-06-29 | GSE2459 | GEO

Myocardial gene expression in response to pressure overload

2015-07-01 | GSE61177 | GEO