Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Genome-wide mapping of p53-binding in 293T cells

ABSTRACT: Genome-wide mapping of p53-binding in 293T cells

PROVIDER: PRJNA645131 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR12185254_1.fastq.gz	Fastqsanger.gz
	SRR12185254_2.fastq.gz	Fastqsanger.gz
	SRR12185255_1.fastq.gz	Fastqsanger.gz
	SRR12185255_2.fastq.gz	Fastqsanger.gz
	SRR12185256_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 16

Similar Datasets

Genome-wide mapping of p53-binding in 293T cells

Project description:We report p53-target genes in response to DNA damage in 293T cells

2021-03-03 | GSE154103 | GEO

Genome-wide mapping of DsbR-binding sites

Project description:Genome-wide mapping of DsbR-binding sites

| PRJNA645568 | ENA

Genome-wide mapping sites of Ulp2 chromatin binding

Project description:Genome-wide mapping sites of Ulp2 chromatin binding

| PRJNA540826 | ENA

Real-time quantitative PCR analysis of Wild-type p53 (Wtp53) and Mutant p53 (Mutp53) transiently overexpressed in HEK-293T cells

Project description:To identify a novel lncRNA regulated by mutp53. Wtp53 and 5 different hotspots mutation of p53 were transiently transfected into HEK-293T cells and compared with plasmid vector (pcDNA6A-Flag).

2023-10-07 | GSE159185 | GEO

Distinct p53 Genomic Binding Patterns in Normal and Cancer-derived Human Cells

Project description:We report here genome-wide analysis of the tumor suppressor p53 binding sites in normal human cells. 743 high-confidence ChIP-seq peaks representing putative genomic binding sites were identified in normal IMR90 fibroblasts using a reference chromatin sample. More than 40 % were located within 2 kb of a transcription start site (TSS), a distribution similar to that documented for individually studied functional p53 binding sites and to date not observed by previous genome-wide studies. Nearly half of the high-confidence binding sites in the IMR90 cells reside in CpG islands, in marked contrast to sites reported in cancer-derived cells. The distinct genomic features of the IMR90 binding sites do not reflect a distinct preference for specific sequences, since the de novo developed p53 motif based on our study is similar to those reported by genome-wide studies of cancer cells. More likely the different chromatin landscape in normal compared to cancer-derived cells influences p53 binding via modulating availability of the sites. We compared the IMR90 ChIP-seq peaks to the recently published IMR90 methylome1, and demonstrated that they are enriched at hypomethylated DNA. Our study represents the first genome-wide, de novo mapping of p53 binding sites in normal human cells and reveals that p53 binding sites reside in distinct genomic landscapes in normal and cancer-derived human cells. Identification of genomic p53 binding sites in normal human cells by ChIP-seq.

2011-12-08 | E-GEOD-31558 | biostudies-arrayexpress

Exploration of the genome-wide DNA binding of chicken p53 in LMH cells

Project description:To investigate the genome-wide DNA binding of chicken p53, we overexpressed chicken p53 with a flag in LMH cells. We then performed genome-wide DNA binding analysis using data obtained from ChIP-seq of LMH cells.

2022-10-05 | GSE200405 | GEO

Genome-wide mapping of OsHOX24-binding sites in rice

Project description:Genome-wide mapping of OsHOX24-binding sites in rice

| PRJNA603582 | ENA

iCLIP transcriptome-wide mapping of UNR (CSDE1) binding sites

Project description:iCLIP transcriptome-wide mapping of UNR (CSDE1) binding sites

| PRJEB10303 | ENA

Genome-wide mapping of p53-transcriptional activity in the pulmonary endothelium

Project description:Genome-wide mapping of p53-transcriptional activity in the pulmonary endothelium

| PRJNA587160 | ENA

Distinct p53 Genomic Binding Patterns in Normal and Cancer-derived Human Cells

2011-12-08 | GSE31558 | GEO