Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Whole transcriptome analysis for kidney aging in mice [miRNA-seq]

ABSTRACT: Whole transcriptome analysis for kidney aging in mice [miRNA-seq]

PROVIDER: PRJNA645441 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR12195478.fastq.gz	Fastqsanger.gz
	SRR12195479.fastq.gz	Fastqsanger.gz
	SRR12195480.fastq.gz	Fastqsanger.gz
	SRR12195481.fastq.gz	Fastqsanger.gz
	SRR12195482.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 15

Similar Datasets

Whole transcriptome analysis for kidney aging in mice

Project description:Whole transcriptome analysis for kidney aging in mice

| PRJNA645435 | ENA

Whole transcriptome analysis for kidney aging in mice [non-coding RNA]

Project description:Whole transcriptome analysis for kidney aging in mice [non-coding RNA]

| PRJNA645440 | ENA

Whole transcriptome analysis for kidney aging in mice [miRNA-seq]

Project description:The goals of this study are to explore the differential expression of non-coding RNAs in mice kidne during aging

2020-07-11 | GSE154222 | GEO

The miRNA expression signatures in young and aging C57BL/6 mouse kidney

Project description:To identify novel aging-related miRNAs, we initially established a physiological aging mouse model (20-month old male C57BL/6 mouse), compared with 2-month old male C57BL/6 mouse. Then, the Agilent miRNA microarray was performed to profile miRNA expression levels in kidney from 20-month old male C57BL/6 mouse (designated as Aging) and 2-month old male C57BL/6 mouse (designated as Young).

2018-10-01 | GSE106109 | GEO

The miRNA expression signatures in young and aging C57BL/6 mouse kidney

Project description:The miRNA expression signatures in young and aging C57BL/6 mouse kidney

| PRJNA415620 | ENA

Whole transcriptome analysis for kidney aging in mice [non-coding RNA]

Project description:The goals of this study are to explore the differential expression of non-coding RNAs in mice kideny during aging

2020-07-11 | GSE154220 | GEO

miRNA Profile in Kidney of NZBWF1 mice

Project description:miRNA Profile in Kidney of NZBWF1 mice

| PRJNA660637 | ENA

Effect of perinatal obesity on premature kidney aging signaling

Project description:Chronic Kidney Disease (CKD), a global health burden, is strongly associated with age-related renal function decline, hypertension and diabetes, frequent consequences of obesity. Despite extensive studies the mechanisms determining susceptibility to CKD remain elusive. Clinical evidence together with prior studies from our group showed that perinatal metabolic disorders after maternal obesity adversely affect kidney structure and function throughout life. Since obesity and aging processes converge in similar pathways we tested if perinatal obesity induced by High-Fat Diet (HFD)-fed female mice sensitizes aging-associated mechanism in kidneys of newborn mice. Tissue from the kidney cortex and the kidney medulla was collected from offspring of control or HFD-fed mice.

2022-12-31 | E-MTAB-10954 | biostudies-arrayexpress

Revealing regulatory transcription factors of aging in the kidney and kidney through multi-omics analysis

Project description:Aging is accompanied by a gradual loss of systemic metabolic homeostasis, which is maintained by multiple-organs, especially the kidney and kidney. However, a systematic study of the regulatory networks and regulatory transcription factors (TFs) of aging in the kidney and kidney remains lacking. Here, we performed an integrated analysis of multi-omics datasets in the kidney and kidney from young and aged mice, including RNA-seq, reduced representation bisulfite sequencing (RRBS) and ATAC-seq datasets, which indicated that enhanced inflammation and dysregulated metabolism were conserved signatures in aged kidney and kidney in both the transcriptome and epigenome. Transcription factor and regulatory network analysis indicated that activation of AP-1 and SPI1 was responsible for enhanced inflammation, and down-regulation of HNFs and PPARs contributed to dysregulated metabolism in aged kidney and kidney. Importantly, we found that the activation of AP-1 was cellular autonomous in aged hepatic and renal cells. However, enhanced SPI1 was caused by elevated infiltration of macrophages. Importantly, inhibition of AP-1 with small molecule combination attenuated inflammation phenotypes of aging in vivo and in vitro. Taken together, our analysis revealed common signatures and regulatory TFs of aging in the kidney and kidney, providing novel targets for the development of anti-aging interventions.

2021-10-01 | GSE181797 | GEO

miRNA expression in nephron progenitors of the developing kidney

Project description:mIRNA expression profiling of mouse embryonic nephron progenitors at embryonic day 14 isolated by GFP expression driven by Six2-TGC (transgenic mouse line), compared to whole embryonic kidney at day 14

2017-02-01 | GSE86217 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data