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Methylation and gene expression data obtained from Dnmt3b+/- peripheral T-cell lymphomas.

ABSTRACT: Methylation and gene expression data obtained from Dnmt3b+/- peripheral T-cell lymphomas.

PROVIDER: PRJNA645699 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12203405_1.fastq.gz	Fastqsanger.gz
	SRR12203405_2.fastq.gz	Fastqsanger.gz
	SRR12203406_1.fastq.gz	Fastqsanger.gz
	SRR12203406_2.fastq.gz	Fastqsanger.gz
	SRR12203407_1.fastq.gz	Fastqsanger.gz

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Methylation and gene expression data obtained from Dnmt3b+/- peripheral T-cell lymphomas.

Project description:Dnmt3b is a tumor suppressor in oncogene-driven lymphoid and myeloid malignancies in mice. However, it is poorly understood whether reduced Dnmt3b activities can initiate malignant hematopoiesis. We modulated Dnmt3b activity in vivo by generating Dnmt3b+/− mice expressing one wild-type allele. Here, we analyzed methylation and gene expression in Dnmt3b+/- peripheral T-cell lymphomas (PTCLs).

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