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RNA-Seq to identify NMUR-1-regulated genes in C. elegans defense against pathogen infection

ABSTRACT: RNA-Seq to identify NMUR-1-regulated genes in C. elegans defense against pathogen infection

PROVIDER: PRJNA645889 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR17048600_1.fastq.gz	Fastqsanger.gz
	SRR17048600_2.fastq.gz	Fastqsanger.gz
	SRR17048601_1.fastq.gz	Fastqsanger.gz
	SRR17048601_2.fastq.gz	Fastqsanger.gz
	SRR17048602_1.fastq.gz	Fastqsanger.gz

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RNA-Seq to identify NMUR-1-regulated genes in C. elegans defense against pathogen infection

Project description:To gain molecular insights on how NMUR-1 regulates C. elegans defense against pathogen infection, we used RNA-Seq to profile gene expression in nmur-1(ok1387) animals relative to wild-type animals with or without E. faecalis or S. enterica infection. We found that NMUR-1 modulates C. elegans transcription activity by regulating the expression of transcription factors, which, in turn, controls the expression of distinct immune genes in response to different pathogens.

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