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Blood-Tumor overlapping TCR repertoire predicts the clinical responses of PD-1 blockade in patients with gastrointestinal cancer [TCR-Seq]

ABSTRACT: Blood-Tumor overlapping TCR repertoire predicts the clinical responses of PD-1 blockade in patients with gastrointestinal cancer [TCR-Seq]

PROVIDER: PRJNA646627 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12234214.fastq.gz	Fastqsanger.gz
	SRR12234215.fastq.gz	Fastqsanger.gz
	SRR12234216.fastq.gz	Fastqsanger.gz
	SRR12234217.fastq.gz	Fastqsanger.gz
	SRR12234218.fastq.gz	Fastqsanger.gz

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Blood-Tumor overlapping TCR repertoire predicts the clinical responses of PD-1 blockade in patients with gastrointestinal cancer [TCR-Seq]

Project description:As the anti-PD-1 monoclonal antibody (mAb) becomes to be used in many types of cancers, the needs for the predictive biomarker of PD-1 blockade are growing. T cell receptor (TCR) repertoire—which reflects the anti-tumor T-cell responses based on the antigen specificity—is a potential biomarker of cancer immunotherapy. Here, we analyzed the TCR repertoire of patients with advanced gastrointestinal cancer and explored its association with clinical responses.

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Project description:This SuperSeries is composed of the SubSeries listed below.

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