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A distinct CD38+CD45RA+ population of CD4+, CD8+ and double-negative T cells is controlled by FAS (II)

ABSTRACT: A distinct CD38+CD45RA+ population of CD4+, CD8+ and double-negative T cells is controlled by FAS (II)

PROVIDER: PRJNA647893 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12298086.fastq.gz	Fastqsanger.gz
	SRR12298087.fastq.gz	Fastqsanger.gz
	SRR12298088.fastq.gz	Fastqsanger.gz
	SRR12298089.fastq.gz	Fastqsanger.gz
	SRR12298090.fastq.gz	Fastqsanger.gz

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A distinct CD38+CD45RA+ population of CD4+, CD8+ and double-negative T cells is controlled by FAS (II)

Project description:The identification and characterization of rare immune cell populations in humans can be facilitated by their growth advantage in the context of specific genetic diseases. Here, we use autoimmune-lymphoproliferative syndrome to identify a population of FAS-controlled TCRab+ T cells. They include CD4+, CD8+ and double-negative T cells and can be defined by a CD38+CD45RA+T-BET- expression pattern. These unconventional T cells are present in all healthy individuals, generated before birth, enriched in lymphoid tissue and do not expand during acute viral infection. They are characterized by a unique molecular signature that is unambiguously different from other known T-cell differentiation subsets and independent of CD4 or CD8 expression. Functionally, FAS-controlled T cells represent highly proliferative, non-cytotoxic T cells with IL-10 cytokine bias. Mechanistically, regulation of this physiologic population is mediated by FAS and CTLA4 signaling and its survival is enhanced by mTOR and STAT3 signals. Genetic alterations in these pathways result in expansion of FAS-controlled T cells, which can cause significant lymphoproliferative disease.

2020-10-29 | GSE154928 | GEO

A distinct CD38+CD45RA+ population of CD4+, CD8+ and double-negative T cells is controlled by FAS (I)

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A distinct CD38+CD45RA+ population of CD4+, CD8+ and double-negative T cells is controlled by FAS

Project description:A distinct CD38+CD45RA+ population of CD4+, CD8+ and double-negative T cells is controlled by FAS

| PRJNA647888 | ENA

A distinct CD38+CD45RA+ population of CD4+, CD8+ and double-negative T cells is controlled by FAS (I)

Project description:A distinct CD38+CD45RA+ population of CD4+, CD8+ and double-negative T cells is controlled by FAS (I)

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A distinct CD38+CD45RA+ population of CD4+, CD8+, and double-negative T cells is controlled by FAS.

Project description:The identification and characterization of rare immune cell populations in humans can be facilitated by their growth advantage in the context of specific genetic diseases. Here, we use autoimmune lymphoproliferative syndrome to identify a population of FAS-controlled TCRαβ+ T cells. They include CD4+, CD8+, and double-negative T cells and can be defined by a CD38+CD45RA+T-BET- expression pattern. These unconventional T cells are present in healthy individuals, are generated before birth, are enriched in lymphoid tissue, and do not expand during acute viral infection. They are characterized by a unique molecular signature that is unambiguously different from other known T cell differentiation subsets and independent of CD4 or CD8 expression. Functionally, FAS-controlled T cells represent highly proliferative, noncytotoxic T cells with an IL-10 cytokine bias. Mechanistically, regulation of this physiological population is mediated by FAS and CTLA4 signaling, and its survival is enhanced by mTOR and STAT3 signals. Genetic alterations in these pathways result in expansion of FAS-controlled T cells, which can cause significant lymphoproliferative disease.

| S-EPMC7658692 | biostudies-literature

A distinct CD38+CD45RA+ population of CD4+, CD8+ and double-negative T cells is controlled by FAS

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-10-29 | GSE154929 | GEO

Single cell RNA-sequencing (scRNA-seq) of the human hematopoietic stem cell compartment (CD34+CD38-CD45RA-)

Project description:To identify a trajectory of human hematopoietic stem cell (HSC) activation we performed scRNAseq of CD34+CD38—CD45RA—cells from G-CSF-mobilized peripheral blood from 3 donors. We show that INKA1 and CDK6/PAK4 expressing single cells segregate across alternative states of quiescence.

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A survival mechanism controlled by cadherins and Dlg1 polarity complex inhibits Fas cell death receptor signaling

Project description:A fine regulation of epithelia cell death is required to maintain tissue integrity and homeostasis. At a cellular level, this life and death decision is controlled by environmental stimuli including death receptors activation. Here, we show that establishment of cell polarity and AJ formation control the pro-apoptotic signaling emanating from the death receptor Fas. We demonstrate that in colon epithelia Fas concentrates at cell-cell junctions together with the E-cadherin, which protects cells from FasL-induced cell death. The Fas-cadherin association requires the C terminal PDZ binding site of Fas and, using a proteomic approach, we showed that this domain allows the association with the polarity molecule Dlg1. We proved that the interaction of Fas with this scaffold molecule participate to this cell death protection. Therefore inhibition of FasL-induced cell death by Fas-cadherin-Dlg1 complex is a double-edged sword mechanism that helps to maintain epithelial homeostasis by (i) protecting normal polarized epithelia from apoptosis (ii) promoting the elimination of compromised non-polarized cells.

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Effect of IL12 on clonal CD8+ CD45RA+ population

Project description:Effector memory T-cell clones against well known tumor antigens (STEAP1, PRAME; CD8+, CD45RA+) were or were not treated with 10ng/ml IL12 and analyzed after 12 and 48 hours

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Single cell RNA-sequencing (scRNA-seq) of the human hematopoietic stem cell compartment (CD34+CD38-CD45RA-)

Project description:Single cell RNA-sequencing (scRNA-seq) of the human hematopoietic stem cell compartment (CD34+CD38-CD45RA-)

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