Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mouse transcriptome of two genetic mutations of Grm1

ABSTRACT: Mouse transcriptome of two genetic mutations of Grm1

PROVIDER: PRJNA649166 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR12338630_1.fastq.gz	Fastqsanger.gz
	SRR12338630_2.fastq.gz	Fastqsanger.gz
	SRR12338631_1.fastq.gz	Fastqsanger.gz
	SRR12338631_2.fastq.gz	Fastqsanger.gz
	SRR12338632_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 24

Similar Datasets

Mouse transcriptome of two genetic mutations of Grm1

Project description:We report two genetic mutations of GRM1, which are Grm1-S458A and Grm1b-R889W, identified from two natural short sleep families. The introduction of these mutations into mouse models also causes the mice to sleepless. Thus, these findings suggest GRM1 is another short sleep gene and highlight the essential roles of mGluRs in regulating human sleep.

2020-10-16 | GSE155252 | GEO

Intergenerational genetic effects on the mouse transcriptome

Project description:Intergenerational genetic effects on the mouse transcriptome

| PRJEB70518 | ENA

Genetic characterization of T-PLL reveals two major biologic subgroups and JAK3 mutations as prognostic marker

Project description:T-cell prolymphocytic leukemia (T-PLL) is a rare post-thymic T-cell neoplasm with aggressive clinical course and short overall survival. So far, due to the rareness of this disease, genetic data is available only from individual cases or small cohorts. In our study, we aimed at performing a comprehensive cytogenetic and molecular genetic characterization of T-PLL comprising the largest cohort of patients with T-PLL analyzed so far, including correlations between the respective markers and their impact on prognosis. Genetic abnormalities were found in all 51 cases with T-PLL, most frequently involving the TCRA/D locus (86%). Deletions were detected for ATM (69%) and TP53 (31%), whereas i(8)(q10) was observed in 61% of cases. Mutations in ATM, TP53, JAK1 and JAK3 were detected in 73%, 14%, 6%, and 21% of patients, respectively. Additionally, BCOR mutations were observed for the first time in a lymphoid malignancy (8%). Two distinct genetic subgroups of T-PLL were identified: A large subset (86% of patients) showed abnormalities involving the TCRA/D locus activating the proto-oncogenes TCL1 or MTCP1, while the second group was characterized by a high frequency of TP53 mutations (4/7 cases). Further, analyses of overall survival identified JAK3 mutations as important prognostic marker, showing a significant negative impact.

2015-02-05 | GSE65649 | GEO

Transcriptome characterization of CHOPS syndrome, a novel genetic disorder caused by gain-of-function mutations of AFF4

Project description:AFF4 is a component of super elongation complex (SEC), which plays an important role in mobilizing paused RNA polymerase II at gene promoter regions. Using exome sequenging, we have identified a novel genetic disorder caused by missense mutations in AFF4. We propose CHOPS syndrome as a name for this new diagnosis. To evaluate the effect of identified missense mutations of AFF4, utilizing patient derived skin fibroblast cell lines, the gene expression analysis was perfomred. To characterize the transcriptome pattern observed in CHOPS syndrome, the skin fibroblast samples from two CHOPS syndrome probands and three healthy control subjects were used. Samples used for expression array include two CHOPs syndrome samples (CDL160: 6 year-old Caucasian female with 254S mut and CDL444: 12 year-old Caucasian male with 254A mut) and three age gender matched controls (GM01652: 11 year-old Caucasian female, GM02036 11 year-old Caucasian female and GM08398: 8 year-old Caucasian male).

2015-01-27 | E-GEOD-64031 | biostudies-arrayexpress

Effect of Fnip2 genetic variant in mouse tissues

Project description:We have modeled the Fnip2 rs2291007 genetic variant in the mouse genome. In this study we aimed to investigate the effect of this genetic variant in the transcriptome of two metabolically relevant tissues: liver and white adipose tissue (WAT)

2022-10-19 | GSE200620 | GEO

The Genetic Landscape of Mutations in Burkitt Lymphoma

Project description:The Genetic Landscape of Mutations in Burkitt Lymphoma

| PRJNA178385 | ENA

Exome mutations in mouse LMP1 Lymphomas

Project description:Exome mutations in mouse LMP1 Lymphomas

| PRJNA561167 | ENA

Next-generation Sequencing of Colorectal Cancer Somatic Cells to Guide Genetic Susceptibility Gene Mutations Screening.

Project description:This is a prospective, single-center, clinical study.This study is to evaluate the feasibility of genetic susceptibility screening based on the detection of tumor tissue mutations by a NGS panel.

| 2330960 | ecrin-mdr-crc

Mouse Gsr-null liver transcriptome

Project description:Genetic disruption of Gsr in mouse elicits only subtle changes in the liver transcriptome. Transcriptome analysis of Gsr-null livers was performed to further our understanding of pathways that may compensate for loss of Gsr, one of the two NADPH-dependent cytosolic disulfide reductases.

2019-05-01 | GSE124444 | GEO

STAG1 Mutations in Genetic Predisposition to Childhood hematological malignancies

Project description:STAG1 Mutations in Genetic Predisposition to Childhood hematological malignancies

| PRJEB52940 | ENA