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Next Generation Sequencing Facilitates Quantitative Analysis of ob/+ and ob/ob pancreatic islet Transcriptomes

ABSTRACT: Next Generation Sequencing Facilitates Quantitative Analysis of ob/+ and ob/ob pancreatic islet Transcriptomes

PROVIDER: PRJNA655612 | ENA |

REPOSITORIES: ENA

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Next Generation Sequencing Facilitates Quantitative Analysis of ob/+ and ob/ob pancreatic islet Transcriptomes

Project description:Purpose:To identify which genes are differentially expressed in pancreatic islets of the ob/ob mice compared to the control ob/+ mice Methods: The data were aligned to mm10 reference genome with HISAT2 (V2.1.0).Differential expression analysis was performed using the DESeq2(V 1.2.0). Results:Library construction, and sequencing were performed by Beijing Genomic Institution (www.genomics.org.cn, BGI) using an optimized data analysis workflow

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Project description:Bariatric surgical techniques are known to cause weight loss and diabetes remission to varying degrees in severly obese patients. However, the mechanisms involved in the restoration of beta-cell function remain to be uncovered. In this study, the leptin-deficient ob/ob mouse was used as a model to investigate the effect of EGA bariactric surgery on pancreatic islet gene expression.

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Gene expression in diabetes-prone (NZO/HiBomDife) and diabetes-resistant (C57BL/6.V-Lepob/ob) mouse strains

Project description:Mouse strains like NZO and B6-ob/ob differ in their susceptibility to diet-induced diabetes. Comparison of the islet transcriptomes leads to genes that are either involved in protection or apoptosis of pancreatic islet cells upon carbohydrate challenge. Genes being upregulated in NZO can be seen as drivers of beta cell failure, while genes upregulated in B6-ob/ob are most likely involved in beta cell protection.

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