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ScRNASeq data of CD45+CD3-CD19- and keratinocytes in normal and HS skin

ABSTRACT: scRNASeq data of CD45+CD3-CD19- and keratinocytes in normal and HS skin

PROVIDER: PRJNA655752 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12404757.fastq.gz	Fastqsanger.gz
	SRR12404758.fastq.gz	Fastqsanger.gz
	SRR12404759.fastq.gz	Fastqsanger.gz
	SRR12404760.fastq.gz	Fastqsanger.gz
	SRR12404761.fastq.gz	Fastqsanger.gz

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scRNASeq data of CD45+CD3-CD19- and keratinocytes in normal and HS skin

Project description:Hidradenitis suppurativa (HS) is a highly prevalent, morbid inflammatory skin disease with limited treatment options. The major cell types and inflammatory pathways in skin of HS patients are poorly understood. We profiled via scRNASeq myeloid cells and keratinocytes sort-purified from two healthy skin samples and two samples with HS pathology to determine major cell types and transcriptional pathways altered in HS.

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Project description:Hidradenitis suppurativa (HS) is an inflammatory skin disease with limited therapeutic options. We and others have previously identified an abnormal B cell infiltrate within HS lesional skin. We performed scRNASequencing on CD3 negative cells from inflammatory HS skin lesions, healthy control skin and matched blood to better understand infiltrating B cells amongst other immune cells within lesional skin.

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