Project description:Genome wide association studies of plasma lipid traits suggest a potential link between ILRUN and plasma cholesterol homeostasis. In this study, we sought to study the in vivo role of ILRUN in lipid metabolism. The transcriptional effects of Ilrun deficiency on mouse liver was unknown. We isolated livers from control and global IlrunKO mice for transcriptomic profiling.
Project description:To investigate the potential mechanism by which RECS1 regulate metabolic disorder, we treated control mice and RECS1 HKO mice with HFD for 8 weeks, and performed microarray to identify the expression pattern and the potential important molecules regulated by RECS1. We used microarrays to detect the global gene expression in the livers of control mice and RECS1 HKO mice after treatment with HFD for 8 weeks and identified distinct classes of altered genes in the livers of mice upon HFD compared .
Project description:Transcriptional profiling of mouse livers comparing control mice with miR-155 transgenic mice that overexpression of miR-155 in the liver
Project description:Sco1 is a gene required for cytochrome c oxidase biogenesis and the regulation of copper homeostasis. We characterized the transcriptional changes that occur as a result of liver-specific deletion of Sco1 in mice at 27 days of age In this dataset, we include the expression data obtained from dissected wild-type mouse livers and mouse livers in which Sco1 has been specifically deleted.