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Genome wide screening for binding target of ELF3 transcription factor in biliary epithrial cell line HBDEC2

ABSTRACT: Genome wide screening for binding target of ELF3 transcription factor in biliary epithrial cell line HBDEC2

PROVIDER: PRJNA656951 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12445161.fastq.gz	Fastqsanger.gz
	SRR12445162.fastq.gz	Fastqsanger.gz

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Genome wide screening for binding target of ELF3 transcription factor in biliary epithrial cell line HBDEC2

Project description:ELF3, a member of E26 transformation-specific transcription factors, is inactivated in a range of cancers including biliary tract cancer. We performed chromatin immunoprecipitation followed by high-throughput DNA sequencing (ChIP-Seq) to identify direct ELF3 target genes. The number of uniquely mapped reads identified by ChIP-Seq was 109.9 M for the ELF3 binding site and 59.7 M for the control input DNA. These read data were evaluated with MACS 1.4, and 13,960 peaks were identified throughout the genome with a false discovery rate (FDR) of < 0.1.

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