Project description:Pulmonary arterial hypertension (PAH) is a progressive fatal disease that is characterized by pathological pulmonary artery remodeling, in which endothelial cell (EC) dysfunction is critically involved. We herein describe a previously unknown role of endothelial angiocrine in pulmonary hypertension. By searching for genes highly expressed in lung microvascular ECs, we identified inhibin--A (INHBA) as an angiocrine factor produced by pulmonary capillaries. We found that excess production of INHBA by ECs impairs the endothelial function in an autocrine manner by functioning as activin A (ActA). Mechanistically, ActA induces bone morphogenetic protein receptor type 2 (BMPRII) internalization and targeting to lysosomes for degradation, resulting in BMPRII signal deficiency in ECs. When endothelial ActA-BMPRII link is overdriven in mice, hypoxia-induced pulmonary hypertension was exacerbated, whereas conditional knockout of INHBA in ECs prevents the progression of pulmonary hypertension. These data collectively indicate a critical role for the dysregulated endothelial ActA-BMPRII link in the progression of pulmonary hypertension, and thus endothelial INHBA/ActA is an attractive pharmacotherapeutic target for the treatment of PAH.

2020-12-15 | GSE156233 | GEO

A topological cluster of differentially regulated genes in mice lacking PER3

Project description:A topological cluster of differentially regulated genes in mice lacking PER3

| PRJNA601182 | ENA

Identification of differentially expressed tumour-related genes regulated by UHRF1 regulated DNA methylation [RNA-Seq]

Project description:Identification of differentially expressed tumour-related genes regulated by UHRF1 regulated DNA methylation [RNA-Seq]

| PRJNA1045263 | ENA

Transcription profiling of human squamous lung cancer cells vs normal cells to identify genes that are differentially regulated

Project description:Gene expression profile of squamous lung cancer cells are used to identify genes that are differentially regulated. Experiment Overall Design: Each pair of samples represent a single patient with squamous lung cancer. One is derived from the cancer cells, and the other is from the normal cells. Five patients, with two arrays for each patients.

2007-09-05 | E-GEOD-3268 | biostudies-arrayexpress

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