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Ddx10 functions as a positive regulator of somatic cell reprogramming

ABSTRACT: Ddx10 functions as a positive regulator of somatic cell reprogramming

PROVIDER: PRJNA658512 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12491474_1.fastq.gz	Fastqsanger.gz
	SRR12491474_2.fastq.gz	Fastqsanger.gz
	SRR12491475_1.fastq.gz	Fastqsanger.gz
	SRR12491475_2.fastq.gz	Fastqsanger.gz
	SRR12491476_1.fastq.gz	Fastqsanger.gz

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Ddx10 functions as a positive regulator of somatic cell reprogramming

Project description:RNA-binding proteins (RBPs) function in all steps of cellular RNA metabolism. Here, we find that Ddx10 gain-of-function promotes but loss-of-function impedes somatic cell reprogramming. Ddx10 loss-of-function results in significantly abnormal expression of innate immune response genes at the late stage of reprogramming. Knockdown of interferon transcription factor Irf1 or its downstream targets, Igtp and Tgtp2, respectively, obviously inhibited reprogramming. This study revealed that Ddx10 regulated reprogramming through modulating innate immune network.

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RNA helicase DDX10 is Required for Pluripotency of Stem Cells by Regulating 18S rRNA Processing (RNA-Seq)

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