Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Simulated Gastrointestinal Model

ABSTRACT: Simulated Gastrointestinal Model Targeted loci environmental

PROVIDER: PRJNA658988 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR12541400_1.fastq.gz	Fastqsanger.gz
	SRR12541400_2.fastq.gz	Fastqsanger.gz
	SRR12541401_1.fastq.gz	Fastqsanger.gz
	SRR12541401_2.fastq.gz	Fastqsanger.gz
	SRR12541402_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 192

Similar Datasets

in vitro simulated gastrointestinal model

Project description:In vitro simulated gastrointestinal model Targeted loci environmental

| PRJNA565012 | ENA

Gastrointestinal microbiota of children with short bowel syndrome

Project description:Gastrointestinal microbiota of children with short bowel syndrome Targeted loci environmental

| PRJNA492751 | ENA

Gene expression profile of Lactobacillus casei Zhang in fermented milk during transit in simulated gastrointestinal tract

2011-12-31 | GSE23685 | GEO

Gene expression profile of Lactobacillus casei Zhang in fermented milk during transit in simulated gastrointestinal tract

Project description:The survival of probiotics could be strongly enhanced by delivery vehicles, but the mechanism was unknown. In this study, whole genome microarray technology was used to detect the gene expression profiles of probiotic Lactobacillus casei Zhang in the absence and presence of fermented milk in simulated gastrointestinal tract. The results showed the gene expression profiles were significantly different under these two different conditions. The change of the gene expression profile may be helpful to comprehend the role of delivery vehicles in enhancing the survival of probiotics. Twelve samples of bacterial cells in the absence and presence of fermented milk were collected at 3 h in simulated gastric juice, 4 h and 8 h in intestinal juice, 2 biological replicates were obtained in each time point. The average of the normalized expression values of the 2 biological replicates for each probe was regarded as the expression value of a predicted gene. To identify the expression pattern of each gene across different treatments, n-fold change ratios were calculated for every gene in pure L. casei Zhang versus L. casei Zhang in fermented milk.

2011-12-31 | E-GEOD-23685 | biostudies-arrayexpress

aquatic metagenome

Project description:Simulated water tanks targeted loci environmental

| PRJNA282572 | ENA

Effect of human child or adult digestion reproduced in a dynamic in vitro gastrointestinal model on Cryptosporidium parvum transcriptome

Project description:The impact of digestive physicochemical parameters on Cryptosporidium parvum transcriptome was analysed in a human and age-dependent context using a dynamic in vitro gastrointestinal model. The sophisticated TIM-1 in vitro model was used for a comparative analysis of C. parvum gene expression under the digestive conditions encountered in young children (from 6 months to 2 years) or in adults following the simulated ingestion of a glass of water contaminated with C. parvum oocysts. The C. parvum gene expression profile was analysed by RNA-sequencing in the inoculum, as well as the gastric and ileal effluents collected from the TIM-1 system. Results showed that time and compartment of digestion lead to the strongest modification of parasite transcriptome. Accordingly, the highest number of differentially expressed genes was observed in parasite samples collected in child or adult ileal effluents between 120 and 180 min of digestion, where invasive stages (sporozoites) are predominant.

2024-07-10 | GSE271211 | GEO

Expression of miRNA, lncRNA and mRNA in human lymphoblastoid TK6 cells under simulated microgravity after ionizing radiation

Project description:In space, multiple unique environmental factors, particularly microgravity and space radiation, pose constant threat to the astronaut’s health. To gain insight into the role of miRNAs and lncRNAs in response to radiation and microgravity, we analyzed RNA expression profiles in human lymphoblastoid TK6 cells incubated for 24 h in static condition or in rotating condition to stimulate microgravity in space after 2 Gy γ-ray irradiation. Expression of 14 lncRNAs and 17 mRNAs was found to be significantly down-regulated in the simulated microgravity condition. In contrast, irradiation up-regulated the expression of 55 lncRNAs and 56 mRNAs, while only one lncRNA, but no mRNA, was down-regulated. Furthermore, 2 miRNAs, 70 lncRNAs, and 87 mRNAs showed significantly altered expression under simulated microgravity after irradiation, and these changes were independently induced by irradiation and simulated microgravity. Together, our results indicate that simulated microgravity and irradiation additively and independently alter the expression of RNAs and their target genes in human lymphoblastoid cells.

2019-09-06 | GSE136939 | GEO

hot springs metagenome

Project description:environmental Targeted loci environmental

| PRJNA362987 | ENA

ZNF-mediated resistance to imatinib mesylate in gastrointestinal stromal tumor

Project description:siRNA knock-down of ZNF genes determined to impact gastrointestinal stromal tumor response to imatinib were used to determine functional significance of ZNFs and identify key targets related to imatinib resistance. exploratory array design to identify candidate effector genes for targeted study

2013-08-01 | E-GEOD-40080 | biostudies-arrayexpress

Murine model of gastrointestinal stromal tumors harboring a germline Kit K641E oncogenic mutant

Project description:Gastrointestinal stromal tumors (GIST) are thought to derive from the interstitial cells of Cajal (ICC) or an ICC precursor. Oncogenic mutations of the receptor tyrosine kinase KIT are present in most GIST. KIT K642E was originally identified in sporadic GIST and later found in the germ line of a familial GIST. A mouse model of harboring a germline Kit K641E mutant was created to model familial GIST. The expression profile was investigated in the gastric antrum in the knock-in Kit K641E murine GIST model by microarray.

2009-09-25 | GSE12931 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data